Phenylalanine-tRNA ligase


Phenylalanine-tRNA ligase

In enzymology, a phenylalanine-tRNA ligase (EC number|6.1.1.20) is an enzyme that catalyzes the chemical reaction

:ATP + L-phenylalanine + tRNAPhe ightleftharpoons AMP + diphosphate + L-phenylalanyl-tRNAPhe

The 3 substrates of this enzyme are ATP, L-phenylalanine, and tRNA(Phe), whereas its 3 products are AMP, diphosphate, and L-phenylalanyl-tRNA(Phe).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-phenylalanine:tRNAPhe ligase (AMP-forming). Other names in common use include phenylalanyl-tRNA synthetase, phenylalanyl-transfer ribonucleate synthetase, phenylalanine-tRNA synthetase, phenylalanyl-transfer RNA synthetase, phenylalanyl-tRNA ligase, phenylalanyl-transfer RNA ligase, L-phenylalanyl-tRNA synthetase, and phenylalanine translase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1B70, PDB link|1B7Y, PDB link|1EIY, PDB link|1JJC, PDB link|1PYS, PDB link|2AKW, PDB link|2ALY, PDB link|2AMC, PDB link|2CXI, and PDB link|2IY5.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9055-66-7."

Gene Ontology (GO) codes


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