Lysine-tRNA ligase


Lysine-tRNA ligase

In enzymology, a lysine-tRNA ligase (EC number|6.1.1.6) is an enzyme that catalyzes the chemical reaction

:ATP + L-lysine + tRNALys ightleftharpoons AMP + diphosphate + L-lysyl-tRNALys

The 3 substrates of this enzyme are ATP, L-lysine, and tRNA(Lys), whereas its 3 products are AMP, diphosphate, and L-lysyl-tRNA(Lys).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-lysine:tRNALys ligase (AMP-forming). Other names in common use include lysyl-tRNA synthetase, lysyl-transfer ribonucleate synthetase, lysyl-transfer RNA synthetase, L-lysine-transfer RNA ligase, lysine-tRNA synthetase, and lysine translase. This enzyme participates in 3 metabolic pathways: lysine biosynthesis, aminoacyl-trna biosynthesis, and amyotrophic lateral sclerosis (als).

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1BBU, PDB link|1BBW, PDB link|1E1O, PDB link|1E1T, PDB link|1E22, PDB link|1E24, PDB link|1IRX, PDB link|1KRS, PDB link|1KRT, and PDB link|1LYL.

References

*
*
*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|9031-26-9."

Gene Ontology (GO) codes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Lysine-tRNAPyl ligase — In enzymology, a lysine tRNAPyl ligase (EC number|6.1.1.25) is an enzyme that catalyzes the chemical reaction:ATP + L lysine + tRNAPyl ightleftharpoons AMP + diphosphate + L lysyl tRNAPylThe 3 substrates of this enzyme are ATP, L lysine, and… …   Wikipedia

  • Cysteine—tRNA ligase — Identifiers EC number 6.1.1.16 CAS number 37318 56 2 …   Wikipedia

  • D-alanine—poly(phosphoribitol) ligase — Identifiers EC number 6.1.1.13 CAS number 9023 65 8 …   Wikipedia

  • List of EC numbers (EC 6) — This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 6.1: Forming Carbon Oxygen… …   Wikipedia

  • Dihydrolipoyl transacetylase — dihydrolipoyllysine residue acetyltransferase Atomic structure of a single subunit of dihydrolipoyl transacetylase from Azotobacter vinelandii that makes up the structural core of the pyruvate dehydrogenase multienzyme complex.[1] …   Wikipedia

  • List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia

  • metabolism — /meuh tab euh liz euhm/, n. 1. Biol., Physiol. the sum of the physical and chemical processes in an organism by which its material substance is produced, maintained, and destroyed, and by which energy is made available. Cf. anabolism, catabolism …   Universalium

  • Mdm2 — p53 binding protein homolog (mouse) Solution structure of Mdm2. [1] …   Wikipedia

  • Cullin — structure of the cul1 rbx1 skp1 f boxskp2 scf ubiquitin ligase complex Identifiers Symbol Cullin Pfam …   Wikipedia

  • Anaphase-promoting complex — Anaphase Promoting Complex, also called cyclosome (APC/C), is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2)… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.