Cysteine-tRNA ligase


Cysteine-tRNA ligase

In enzymology, a cysteine-tRNA ligase (EC number|6.1.1.16) is an enzyme that catalyzes the chemical reaction

:ATP + L-cysteine + tRNACys ightleftharpoons AMP + diphosphate + L-cysteinyl-tRNACys

The 3 substrates of this enzyme are ATP, L-cysteine, and tRNA(Cys), whereas its 3 products are AMP, diphosphate, and L-cysteinyl-tRNA(Cys).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-cysteine:tRNACys ligase (AMP-forming). Other names in common use include cysteinyl-tRNA synthetase, cysteinyl-transferRNA synthetase, cysteinyl-transfer ribonucleate synthetase, and cysteine translase. This enzyme participates in cysteine metabolism and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1LI5, PDB link|1LI7, and PDB link|1U0B.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37318-56-2."

Gene Ontology (GO) codes


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