Aspartate-tRNA ligase


Aspartate-tRNA ligase

In enzymology, an aspartate-tRNA ligase (EC number|6.1.1.12) is an enzyme that catalyzes the chemical reaction

:ATP + L-aspartate + tRNAAsp ightleftharpoons AMP + diphosphate + L-aspartyl-tRNAAsp

The 3 substrates of this enzyme are ATP, L-aspartate, and tRNA(Asp), whereas its 3 products are AMP, diphosphate, and L-aspartyl-tRNA(Asp).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-aspartate:tRNAAsp ligase (AMP-forming). Other names in common use include aspartyl-tRNA synthetase, aspartyl ribonucleic synthetase, aspartyl-transfer RNA synthetase, aspartic acid translase, aspartyl-transfer ribonucleic acid synthetase, and aspartyl ribonucleate synthetase. This enzyme participates in alanine and aspartate metabolism and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1ASY, PDB link|1ASZ, PDB link|1B8A, PDB link|1C0A, PDB link|1EFW, PDB link|1EOV, PDB link|1EQR, PDB link|1G51, PDB link|1IL2, and PDB link|1L0W.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9027-32-1."

Gene Ontology (GO) codes


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