O-pyrocatechuate decarboxylase


O-pyrocatechuate decarboxylase
o-pyrocatechuate decarboxylase
Identifiers
EC number 4.1.1.46
CAS number 37289-48-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an o-pyrocatechuate decarboxylase (EC 4.1.1.46) is an enzyme that catalyzes the chemical reaction

2,3-dihydroxybenzoate \rightleftharpoons catechol + CO2

Hence, this enzyme has one substrate, 2,3-dihydroxybenzoate, and two products, catechol and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2,3-dihydroxybenzoate carboxy-lyase (catechol-forming). This enzyme is also called 2,3-dihydroxybenzoate carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation and carbazole degradation.

References

  • Rao PV, Moore K, Towers GH (1967). "O-pyrocatechiuc acid carboxy-lyase from Aspergillus niger". Arch. Biochem. Biophys. 122 (2): 466–73. doi:10.1016/0003-9861(67)90220-2. PMID 6066253.