Anthranilate synthase

Anthranilate synthase

In enzymology, an anthranilate synthase (EC number|4.1.3.27) is an enzyme that catalyzes the chemical reaction

:chorismate + L-glutamine ightleftharpoons anthranilate + pyruvate + L-glutamate

Thus, the two substrates of this enzyme are chorismate and L-glutamine, whereas its 3 products are anthranilate, pyruvate, and L-glutamate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is chorismate pyruvate-lyase (amino-accepting; anthranilate-forming). Other names in common use include anthranilate synthetase, chorismate lyase, and chorismate pyruvate-lyase (amino-accepting). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and two-component system - general.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1I1Q, PDB link|1I7Q, PDB link|1I7S, PDB link|1QDL, and PDB link|2I6Y.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9031-59-8."

Gene Ontology (GO) codes


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