4-carboxymuconolactone decarboxylase

In enzymology, a 4-carboxymuconolactone decarboxylase (EC number|4.1.1.44) is an enzyme that catalyzes the chemical reaction

:2-carboxy-2,5-dihydro-5-oxofuran-2-acetate $ightleftharpoons$ 4,5-dihydro-5-oxofuran-2-acetate + CO₂

Hence, this enzyme has one substrate, 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate, and two products, 4,5-dihydro-5-oxofuran-2-acetate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming). Other names in common use include gamma-4-carboxymuconolactone decarboxylase, and 4-carboxymuconolactone carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|2AF7.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37289-46-6."

Gene Ontology (GO) codes