Methylmalonyl-CoA carboxytransferase


Methylmalonyl-CoA carboxytransferase
methylmalonyl-CoA carboxytransferase
Identifiers
EC number 2.1.3.1
CAS number 9029-86-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a methylmalonyl-CoA carboxytransferase (EC 2.1.3.1) is an enzyme that catalyzes the chemical reaction

(S)-methylmalonyl-CoA + pyruvate \rightleftharpoons propanoyl-CoA + oxaloacetate

Thus, the two substrates of this enzyme are (S)-methylmalonyl-CoA and pyruvate, whereas its two products are propanoyl-CoA and oxaloacetate.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the carboxy- and carbamoyltransferases. The systematic name of this enzyme class is (S)-methylmalonyl-CoA:pyruvate carboxytransferase. Other names in common use include transcarboxylase, methylmalonyl coenzyme A carboxyltransferase, methylmalonyl-CoA transcarboxylase, oxalacetic transcarboxylase, methylmalonyl-CoA carboxyltransferase, methylmalonyl-CoA carboxyltransferase, (S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase, (S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxytransferase, and carboxytransferase [incorrect]. This enzyme participates in propanoate metabolism. It has 3 cofactors: zinc, Biotin, and Cobalt.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1DCZ, 1DD2, 1ON3, 1ON9, 1RQB, 1RQE, 1RQH, 1RR2, 1S3H, 1U5J, 2D5D, and 2EVB.

References