- Methylmalonyl-CoA carboxytransferase
methylmalonyl-CoA carboxytransferase Identifiers EC number 220.127.116.11 CAS number 9029-86-1 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles
- (S)-methylmalonyl-CoA + pyruvate propanoyl-CoA + oxaloacetate
Thus, the two substrates of this enzyme are (S)-methylmalonyl-CoA and pyruvate, whereas its two products are propanoyl-CoA and oxaloacetate.
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the carboxy- and carbamoyltransferases. The systematic name of this enzyme class is (S)-methylmalonyl-CoA:pyruvate carboxytransferase. Other names in common use include transcarboxylase, methylmalonyl coenzyme A carboxyltransferase, methylmalonyl-CoA transcarboxylase, oxalacetic transcarboxylase, methylmalonyl-CoA carboxyltransferase, methylmalonyl-CoA carboxyltransferase, (S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase, (S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxytransferase, and carboxytransferase [incorrect]. This enzyme participates in propanoate metabolism. It has 3 cofactors: zinc, Biotin, and Cobalt.
- Hoffmann A, Hilpert W, Dimroth P (1989). "The carboxyltransferase activity of the sodium-ion-translocating methylmalonyl-CoA decarboxylase of Veillonella alcalescens". Eur. J. Biochem. 179 (3): 645–50. doi:10.1111/j.1432-1033.1989.tb14596.x. PMID 2920730.
- Swick RW and Wood HG (1960). "The role of transcarboxylation in propionic acid fermentation". Proc. Natl. Acad. Sci. USA 46 (1): 28–41. doi:10.1073/pnas.46.1.28. PMC 285006. PMID 16590594. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=285006.
Transferase: one carbon transferases (EC 2.1) 2.1.1: Methyl-N-O-Other 2.1.2: Hydroxymethyl-,
Formyl- and RelatedHydroxymethyltransferaseFormyltransferaseOther
2.1.3: Carboxy- and CarbamoylCarboxymethylmalonyl-CoA carboxytransferaseCarbamoyl 2.1.4: AmidinoArginine:glycine amidinotransferase This transferase article is a stub. You can help Wikipedia by expanding it.