Phosphatidylinositol diacylglycerol-lyase
- Phosphatidylinositol diacylglycerol-lyase
[
thumb|right|500|Phosphatidylinositol-specific_phospholipase C, image from OPM database] In enzymology, a phosphatidylinositol diacylglycerol-lyase (EC number|4.6.1.13) is an enzyme that catalyzes the chemical reaction
:1-phosphatidyl-1D-myo-inositol 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
Hence, this enzyme has one substrate, 1-phosphatidyl-1D-myo-inositol, and two products, 1D-myo-inositol 1,2-cyclic phosphate and 1,2-diacyl-sn-glycerol.
This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming). Other names in common use include monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, 1-phosphatidylinositol phosphodiesterase, 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase, (cyclic-phosphate-forming), 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase, and (1,2-cyclic-phosphate-forming). This enzyme participates in inositol phosphate metabolism.
tructural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1T6M and PDB link|2OR2.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|37288-19-0."
Gene Ontology (GO) codes
Wikimedia Foundation.
2010.
Look at other dictionaries:
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