In enzymology, a phosphomannomutase (EC number| is an enzyme that catalyzes the chemical reaction

:alpha-D-mannose 1-phosphate ightleftharpoons D-mannose 6-phosphate

Hence, this enzyme has one substrate, alpha-D-mannose 1-phosphate, and one product, D-mannose 6-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is alpha-D-mannose 1,6-phosphomutase. Other names in common use include mannose phosphomutase, phosphomannose mutase, and D-mannose 1,6-phosphomutase. This enzyme participates in fructose and mannose metabolism. It has 2 cofactors: D-glucose 1,6-bisphosphate, and D-Mannose 1,6-bisphosphate.

tructural studies

As of late 2007, 18 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1K2Y, PDB link|1K35, PDB link|1P5D, PDB link|1P5G, PDB link|1PCJ, PDB link|1PCM, PDB link|1WQA, PDB link|2AMY, PDB link|2F7L, PDB link|2FKF, PDB link|2FKM, PDB link|2FUC, PDB link|2FUE, PDB link|2H4L, PDB link|2H5A, PDB link|2I54, PDB link|2I55, and PDB link|2Q4R.



External links

::"The CAS registry number for this enzyme class is CAS registry|59536-73-1."

Gene Ontology (GO) codes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Phosphomannomutase — Bezeichner Gen Name(n) …   Deutsch Wikipedia

  • phosphomannomutase — phos·pho·man·no·mu·tase (fos″fo man″o muґtās) [EC] an enzyme of the isomerase class that catalyzes the interconversion of mannose 6 phosphate and mannose 1 phosphate …   Medical dictionary

  • PMM2 — Phosphomannomutase 2, also known as PMM2, is a human gene.cite web | title = Entrez Gene: PMM2 phosphomannomutase 2| url = Cmd=ShowDetailView TermToSearch=5373| accessdate = ] PBB Summary section… …   Wikipedia

  • PMM1 — Phosphomannomutase 1, also known as PMM1, is a human gene.cite web | title = Entrez Gene: PMM1 phosphomannomutase 1| url = Cmd=ShowDetailView TermToSearch=5372| accessdate = ] PBB Summary section… …   Wikipedia

  • Congenital disorder of glycosylation — Congenital disorders of glycosylation Classification and external resources ICD 10 E77.8 ICD 9 271.8 …   Wikipedia

  • Mutase — A mutase is an enzyme that catalyzes the shifting of a functional group from one position to another within the same molecule. Examples of this are bisphosphoglycerate mutase, which appears in red blood cells and phosphoglycerate mutase, which… …   Wikipedia

  • List of EC numbers (EC 5) — This list contains a list of EC numbers for the fifth group, EC 5, isomerases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. =EC 5.1: Epimerases and… …   Wikipedia

  • Methylmalonyl-CoA mutase — Rendering based on PDB 2XIJ …   Wikipedia

  • ALG6 — Asparagine linked glycosylation 6 homolog (S. cerevisiae, alpha 1,3 glucosyltransferase), also known as ALG6, is a human gene.cite web | title = Entrez Gene: ALG6 asparagine linked glycosylation 6 homolog (S. cerevisiae, alpha 1,3… …   Wikipedia

  • Mannose — Strukturformel Fischer Projektion, offenkettige Darstellung Allgemeines Name …   Deutsch Wikipedia