Cyclin B2


Cyclin B2
Cyclin B2
Identifiers
Symbols CCNB2; HsT17299
External IDs OMIM602755 MGI88311 HomoloGene74359 GeneCards: CCNB2 Gene
RNA expression pattern
PBB GE CCNB2 202705 at tn.png
PBB GE CCNB2 gnf1h06136 s at tn.png
PBB GE CCNB2 gnf1h06137 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9133 12442
Ensembl ENSG00000157456 ENSMUSG00000032218
UniProt O95067 Q922E9
RefSeq (mRNA) NM_004701.3 NM_007630.2
RefSeq (protein) NP_004692.1 NP_031656.2
Location (UCSC) Chr 15:
59.4 – 59.42 Mb
Chr 9:
70.26 – 70.27 Mb
PubMed search [1] [2]

G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.[1]

Contents

See also

Interactions

Cyclin B2 has been shown to interact with TGF beta receptor 2.[2]

References

  1. ^ "Entrez Gene: CCNB2 cyclin B2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9133. 
  2. ^ Liu, J H; Wei S, Burnette P K, Gamero A M, Hutton M, Djeu J Y (Jan. 1999). "Functional association of TGF-beta receptor II with cyclin B". Oncogene (ENGLAND) 18 (1): 269–75. doi:10.1038/sj.onc.1202263. ISSN 0950-9232. PMID 9926943. 

Further reading


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Cyclin D — cyclin D1 Crystal structure of human cyclin D1 (blue/green) in complex with cyclin dependent kinase 4 (yellow/red).[1] Identifiers …   Wikipedia

  • Cyclin A2 — PDB rendering based on 1e9h …   Wikipedia

  • Cyclin B1 — PDB rendering based on 2b9r …   Wikipedia

  • Cyclin A1 — Identifiers Symbols CCNA1; External IDs OMIM:  …   Wikipedia

  • Cyclin E1 — PDB rendering based on 1w98 …   Wikipedia

  • Cyclin D3 — Identifiers Symbols CCND3; External IDs OMIM:  …   Wikipedia

  • Cyclin H — PDB rendering based on 1jkw …   Wikipedia

  • Cyclin D2 — Identifiers Symbols CCND2; KIAK0002; MGC102758 External IDs OMIM:  …   Wikipedia

  • Cyclin T2 — PDB rendering based on 2ivx …   Wikipedia

  • Cyclin T1 — Rendering based on PDB 2PK2 …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.