Sodium-hydrogen antiporter 3


Sodium-hydrogen antiporter 3

Sodium-hydrogen antiporter 3 or Sodium-hydrogen exchanger 3 (NHE3) is an isoform of sodium-hydrogen antiporters. It is found in the nephron of the kidney and is primarily responsible for maintaining the balance of sodium. [ [http://www2.kumc.edu/ki/physiology/course/six/6_1.htm VI. Mechanisms of Salt & Water Reabsorption ] ] [cite web | title = Entrez Gene: SLC9A3 Solute carrier family 9 (sodium/hydrogen exchanger), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6550| accessdate = ]

Regulation

Protein kinase C stimulates NHE3, while protein kinase A inhibits it. 852 cite book |author=Walter F., PhD. Boron |title=Medical Physiology: A Cellular And Molecular Approaoch |publisher=Elsevier/Saunders |location= |year= |pages= |isbn=1-4160-2328-3 |oclc= |doi= Page 852 ]

There is a specific protein functioning as an NHE3 regulator, sodium-hydrogen antiporter 3 regulator 1.

Classification

It is a solute carrier family 9 (sodium/hydrogen exchanger), member 3

Gene

It is encoded by the gene "SLC9A3".

PBB_Summary
section_title =
summary_text =

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=McDonough AA, Leong PK, Yang LE |title=Mechanisms of pressure natriuresis: how blood pressure regulates renal sodium transport. |journal=Ann. N. Y. Acad. Sci. |volume=986 |issue= |pages= 669–77 |year= 2003 |pmid= 12763917 |doi=
*cite journal | author=Orlowski J, Kandasamy RA, Shull GE |title=Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. |journal=J. Biol. Chem. |volume=267 |issue= 13 |pages= 9331–9 |year= 1992 |pmid= 1577762 |doi=
*cite journal | author=Brant SR, Yun CH, Donowitz M, Tse CM |title=Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3. |journal=Am. J. Physiol. |volume=269 |issue= 1 Pt 1 |pages= C198–206 |year= 1995 |pmid= 7631746 |doi=
*cite journal | author=Brant SR, Bernstein M, Wasmuth JJ, "et al." |title=Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3. |journal=Genomics |volume=15 |issue= 3 |pages= 668–72 |year= 1993 |pmid= 8096830 |doi=
*cite journal | author=Colombani V, Silviani V, Marteau C, "et al." |title=Presence of the NHE3 isoform of the Na+/H+ exchanger in human gallbladder. |journal=Clin. Sci. |volume=91 |issue= 2 |pages= 209–12 |year= 1996 |pmid= 8795445 |doi=
*cite journal | author=Dudeja PK, Rao DD, Syed I, "et al." |title=Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA. |journal=Am. J. Physiol. |volume=271 |issue= 3 Pt 1 |pages= G483–93 |year= 1996 |pmid= 8843774 |doi=
*cite journal | author=Lin X, Barber DL |title=A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 22 |pages= 12631–6 |year= 1996 |pmid= 8901634 |doi=
*cite journal | author=Yun CH, Lamprecht G, Forster DV, Sidor A |title=NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25856–63 |year= 1998 |pmid= 9748260 |doi=
*cite journal | author=Biemesderfer D, Nagy T, DeGray B, Aronson PS |title=Specific association of megalin and the Na+/H+ exchanger isoform NHE3 in the proximal tubule. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17518–24 |year= 1999 |pmid= 10364184 |doi=
*cite journal | author=Mobasheri A, Golding S, Pagakis SN, "et al." |title=Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts. |journal=Cell Biol. Int. |volume=22 |issue= 7-8 |pages= 551–62 |year= 1999 |pmid= 10452823 |doi= 10.1006/cbir.1998.0299
*cite journal | author=Trujillo E, Alvarez de la Rosa D, Mobasheri A, "et al." |title=Sodium transport systems in human chondrocytes. II. Expression of ENaC, Na+/K+/2Cl- cotransporter and Na+/H+ exchangers in healthy and arthritic chondrocytes. |journal=Histol. Histopathol. |volume=14 |issue= 4 |pages= 1023–31 |year= 1999 |pmid= 10506918 |doi=
*cite journal | author=Repishti M, Hogan DL, Pratha V, "et al." |title=Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=281 |issue= 1 |pages= G159–63 |year= 2001 |pmid= 11408268 |doi=
*cite journal | author=Malakooti J, Memark VC, Dudeja PK, Ramaswamy K |title=Molecular cloning and functional analysis of the human Na(+)/H(+) exchanger NHE3 promoter. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=282 |issue= 3 |pages= G491–500 |year= 2002 |pmid= 11841999 |doi= 10.1152/ajpgi.00273.2001
*cite journal | author=Gekle M, Serrano OK, Drumm K, "et al." |title=NHE3 serves as a molecular tool for cAMP-mediated regulation of receptor-mediated endocytosis. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 3 |pages= F549–58 |year= 2002 |pmid= 12167607 |doi= 10.1152/ajprenal.00206.2001
*cite journal | author=Kennedy DJ, Leibach FH, Ganapathy V, Thwaites DT |title=Optimal absorptive transport of the dipeptide glycylsarcosine is dependent on functional Na+/H+ exchange activity. |journal=Pflugers Arch. |volume=445 |issue= 1 |pages= 139–46 |year= 2003 |pmid= 12397398 |doi= 10.1007/s00424-002-0910-1
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lee SH, Seok YS, Jung HH, "et al." |title=Expression of mRNA transcripts of the Na+/H+ and Cl-/HCO3- exchanger isoforms in human nasal mucosa. |journal=Acta Otolaryngol. |volume=122 |issue= 8 |pages= 866–71 |year= 2003 |pmid= 12542207 |doi=
*cite journal | author=Inoue H, Nakamura Y, Nagita M, "et al." |title=Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium. |journal=Biol. Pharm. Bull. |volume=26 |issue= 2 |pages= 148–55 |year= 2003 |pmid= 12576672 |doi=
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Sodium–hydrogen antiporter 3 — Solute carrier family 9 (sodium/hydrogen exchanger), member 3 Identifiers Symbols SLC9A3; MGC126718; MGC126720; NHE3 External IDs …   Wikipedia

  • Sodium–hydrogen antiporter — The sodium–hydrogen antiporter or sodium–hydrogen exchanger is a membrane protein found in many cells, and especially in those of the nephron of the kidney. It is primarily responsible for maintaining the balance of sodium.[1] Isoforms There are… …   Wikipedia

  • Sodium-hydrogen antiporter 1 — The Sodium hydrogen antiporter 1 is an isoform of sodium hydrogen antiporters.ClassificationIt is a solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive) , GeneIt is encoded by the gene SLC9A1 .… …   Wikipedia

  • Sodium-hydrogen antiporter — protein Name = solute carrier family 9 (sodium/hydrogen exchanger), member 3 caption = width = HGNCid = 11073 Symbol = SLC9A3 AltSymbols = NHE3 EntrezGene = 6550 OMIM = 182307 RefSeq = NM 004174 UniProt = P48764 PDB = ECnumber = Chromosome = 5… …   Wikipedia

  • Sodium-hydrogen antiporter 3 regulator 1 — Solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 PDB rendering based on 1g9o …   Wikipedia

  • Sodium-hydrogen exchange regulatory cofactor 2 — Solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 PDB rendering based on 2he4 …   Wikipedia

  • Standard hydrogen electrode — NHE redirects here. For the sodium hydrogen exchanger protein, see Sodium hydrogen antiporter. The standard hydrogen electrode (abbreviated SHE), is a redox electrode which forms the basis of the thermodynamic scale of oxidation reduction… …   Wikipedia

  • List of biochemistry topics — This page aims to list articles on Wikipedia that are related to biochemistry. This is so that those interested in the subject can monitor changes to the pages by clicking on .This list is not necessarily complete or up to date if you see an… …   Wikipedia

  • Amiloride — Systematic (IUPAC) name 3,5 diamino 6 chloro N …   Wikipedia

  • МВТР — Обозначения Символы CFTR; CF, ABCC7 …   Википедия