Sodium-hydrogen antiporter 3

Sodium-hydrogen antiporter 3

Sodium-hydrogen antiporter 3 or Sodium-hydrogen exchanger 3 (NHE3) is an isoform of sodium-hydrogen antiporters. It is found in the nephron of the kidney and is primarily responsible for maintaining the balance of sodium. [ [ VI. Mechanisms of Salt & Water Reabsorption ] ] [cite web | title = Entrez Gene: SLC9A3 Solute carrier family 9 (sodium/hydrogen exchanger), member 3| url =| accessdate = ]


Protein kinase C stimulates NHE3, while protein kinase A inhibits it. 852 cite book |author=Walter F., PhD. Boron |title=Medical Physiology: A Cellular And Molecular Approaoch |publisher=Elsevier/Saunders |location= |year= |pages= |isbn=1-4160-2328-3 |oclc= |doi= Page 852 ]

There is a specific protein functioning as an NHE3 regulator, sodium-hydrogen antiporter 3 regulator 1.


It is a solute carrier family 9 (sodium/hydrogen exchanger), member 3


It is encoded by the gene "SLC9A3".

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Further reading

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*cite journal | author=McDonough AA, Leong PK, Yang LE |title=Mechanisms of pressure natriuresis: how blood pressure regulates renal sodium transport. |journal=Ann. N. Y. Acad. Sci. |volume=986 |issue= |pages= 669–77 |year= 2003 |pmid= 12763917 |doi=
*cite journal | author=Orlowski J, Kandasamy RA, Shull GE |title=Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. |journal=J. Biol. Chem. |volume=267 |issue= 13 |pages= 9331–9 |year= 1992 |pmid= 1577762 |doi=
*cite journal | author=Brant SR, Yun CH, Donowitz M, Tse CM |title=Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3. |journal=Am. J. Physiol. |volume=269 |issue= 1 Pt 1 |pages= C198–206 |year= 1995 |pmid= 7631746 |doi=
*cite journal | author=Brant SR, Bernstein M, Wasmuth JJ, "et al." |title=Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3. |journal=Genomics |volume=15 |issue= 3 |pages= 668–72 |year= 1993 |pmid= 8096830 |doi=
*cite journal | author=Colombani V, Silviani V, Marteau C, "et al." |title=Presence of the NHE3 isoform of the Na+/H+ exchanger in human gallbladder. |journal=Clin. Sci. |volume=91 |issue= 2 |pages= 209–12 |year= 1996 |pmid= 8795445 |doi=
*cite journal | author=Dudeja PK, Rao DD, Syed I, "et al." |title=Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA. |journal=Am. J. Physiol. |volume=271 |issue= 3 Pt 1 |pages= G483–93 |year= 1996 |pmid= 8843774 |doi=
*cite journal | author=Lin X, Barber DL |title=A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 22 |pages= 12631–6 |year= 1996 |pmid= 8901634 |doi=
*cite journal | author=Yun CH, Lamprecht G, Forster DV, Sidor A |title=NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25856–63 |year= 1998 |pmid= 9748260 |doi=
*cite journal | author=Biemesderfer D, Nagy T, DeGray B, Aronson PS |title=Specific association of megalin and the Na+/H+ exchanger isoform NHE3 in the proximal tubule. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17518–24 |year= 1999 |pmid= 10364184 |doi=
*cite journal | author=Mobasheri A, Golding S, Pagakis SN, "et al." |title=Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts. |journal=Cell Biol. Int. |volume=22 |issue= 7-8 |pages= 551–62 |year= 1999 |pmid= 10452823 |doi= 10.1006/cbir.1998.0299
*cite journal | author=Trujillo E, Alvarez de la Rosa D, Mobasheri A, "et al." |title=Sodium transport systems in human chondrocytes. II. Expression of ENaC, Na+/K+/2Cl- cotransporter and Na+/H+ exchangers in healthy and arthritic chondrocytes. |journal=Histol. Histopathol. |volume=14 |issue= 4 |pages= 1023–31 |year= 1999 |pmid= 10506918 |doi=
*cite journal | author=Repishti M, Hogan DL, Pratha V, "et al." |title=Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=281 |issue= 1 |pages= G159–63 |year= 2001 |pmid= 11408268 |doi=
*cite journal | author=Malakooti J, Memark VC, Dudeja PK, Ramaswamy K |title=Molecular cloning and functional analysis of the human Na(+)/H(+) exchanger NHE3 promoter. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=282 |issue= 3 |pages= G491–500 |year= 2002 |pmid= 11841999 |doi= 10.1152/ajpgi.00273.2001
*cite journal | author=Gekle M, Serrano OK, Drumm K, "et al." |title=NHE3 serves as a molecular tool for cAMP-mediated regulation of receptor-mediated endocytosis. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 3 |pages= F549–58 |year= 2002 |pmid= 12167607 |doi= 10.1152/ajprenal.00206.2001
*cite journal | author=Kennedy DJ, Leibach FH, Ganapathy V, Thwaites DT |title=Optimal absorptive transport of the dipeptide glycylsarcosine is dependent on functional Na+/H+ exchange activity. |journal=Pflugers Arch. |volume=445 |issue= 1 |pages= 139–46 |year= 2003 |pmid= 12397398 |doi= 10.1007/s00424-002-0910-1
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lee SH, Seok YS, Jung HH, "et al." |title=Expression of mRNA transcripts of the Na+/H+ and Cl-/HCO3- exchanger isoforms in human nasal mucosa. |journal=Acta Otolaryngol. |volume=122 |issue= 8 |pages= 866–71 |year= 2003 |pmid= 12542207 |doi=
*cite journal | author=Inoue H, Nakamura Y, Nagita M, "et al." |title=Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium. |journal=Biol. Pharm. Bull. |volume=26 |issue= 2 |pages= 148–55 |year= 2003 |pmid= 12576672 |doi=
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810

External links


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