DDB2

DDB2
Damage-specific DNA binding protein 2, 48kDa

Rendering based on PDB 3EI4.
Identifiers
Symbols DDB2; DDBB; FLJ34321; UV-DDB2
External IDs OMIM600811 MGI1355314 HomoloGene83 GeneCards: DDB2 Gene
RNA expression pattern
PBB GE DDB2 203409 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1643 107986
Ensembl ENSG00000134574 ENSMUSG00000002109
UniProt Q92466 Q99J79
RefSeq (mRNA) NM_000107.2 NM_028119.5
RefSeq (protein) NP_000098.1 NP_082395.2
Location (UCSC) Chr 11:
47.24 – 47.26 Mb
Chr 2:
91.05 – 91.08 Mb
PubMed search [1] [2]

DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene.[1][2]

DDB2 is the smaller subunit of a heterodimeric protein implicated in the etiology of xeroderma pigmentosum group E. This subunit appears to be required for DNA binding.[3]

Contents

Interactions

DDB2 has been shown to interact with CUL4A,[4] CUL4B[4] and DDB1.[5][6][4]

External Links

References

  1. ^ Keeney S, Chang GJ, Linn S (Nov 1993). "Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E". J Biol Chem 268 (28): 21293–300. PMID 8407967. 
  2. ^ Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S (Feb 1996). "Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein". Genomics 29 (1): 62–9. doi:10.1006/geno.1995.1215. PMID 8530102. 
  3. ^ "Entrez Gene: DDB2 damage-specific DNA binding protein 2, 48kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1643. 
  4. ^ a b c Guerrero-Santoro, Jennifer; Kapetanaki Maria G, Hsieh Ching L, Gorbachinsky Ilya, Levine Arthur S, Rapić-Otrin Vesna (Jul. 2008). "The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A". Cancer Res. (United States) 68 (13): 5014–22. doi:10.1158/0008-5472.CAN-07-6162. PMID 18593899. 
  5. ^ Bergametti, Françoise; Sitterlin Delphine, Transy Catherine (Jul. 2002). "Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex". J. Virol. (United States) 76 (13): 6495–501. doi:10.1128/JVI.76.13.6495-6501.2002. ISSN 0022-538X. PMC 136256. PMID 12050362. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=136256. 
  6. ^ Martinez, E; Palhan V B, Tjernberg A, Lymar E S, Gamper A M, Kundu T K, Chait B T, Roeder R G (Oct. 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. (United States) 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. ISSN 0270-7306. PMC 99856. PMID 11564863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99856. 

Further reading


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