CD69 (Cluster of Differentiation 69) is a human protein encoded by the gene|CD69 gene.

section_title =
summary_text = The activation of T lymphocytes, both in vivo and in vitro, induces expression of CD69. This molecule, which appears to be the earliest inducible cell surface glycoprotein acquired during lymphoid activation, is involved in lymphocyte proliferation and functions as a signal-transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets (Cambiaggi et al., 1992) [supplied by OMIM] .cite web | title = Entrez Gene: CD69 CD69 molecule| url =| accessdate = ]

ee also

* Cluster of differentiation


Further reading

citations =
*cite journal | author=Cambiaggi C, Scupoli MT, Cestari T, "et al." |title=Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12. |journal=Immunogenetics |volume=36 |issue= 2 |pages= 117–20 |year= 1992 |pmid= 1612643 |doi=
*cite journal | author=López-Cabrera M, Muñoz E, Blázquez MV, "et al." |title=Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21545–51 |year= 1995 |pmid= 7665567 |doi=
*cite journal | author=Bezouska K, Nepovím A, Horváth O, "et al." |title=CD 69 antigen of human lymphocytes is a calcium-dependent carbohydrate-binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=208 |issue= 1 |pages= 68–74 |year= 1995 |pmid= 7887967 |doi= 10.1006/bbrc.1995.1306
*cite journal | author=Santis AG, López-Cabrera M, Hamann J, "et al." |title=Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors. |journal=Eur. J. Immunol. |volume=24 |issue= 7 |pages= 1692–7 |year= 1994 |pmid= 8026529 |doi=
*cite journal | author=Ziegler SF, Ramsdell F, Hjerrild KA, "et al." |title=Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. |journal=Eur. J. Immunol. |volume=23 |issue= 7 |pages= 1643–8 |year= 1993 |pmid= 8100776 |doi=
*cite journal | author=López-Cabrera M, Santis AG, Fernández-Ruiz E, "et al." |title=Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. |journal=J. Exp. Med. |volume=178 |issue= 2 |pages= 537–47 |year= 1993 |pmid= 8340758 |doi=
*cite journal | author=Hamann J, Fiebig H, Strauss M |title=Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain. |journal=J. Immunol. |volume=150 |issue= 11 |pages= 4920–7 |year= 1993 |pmid= 8496594 |doi=
*cite journal | author=Krowka JF, Cuevas B, Maron DC, "et al." |title=Expression of CD69 after in vitro stimulation: a rapid method for quantitating impaired lymphocyte responses in HIV-infected individuals. |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=11 |issue= 1 |pages= 95–104 |year= 1996 |pmid= 8528739 |doi=
*cite journal | author=Iafrate AJ, Bronson S, Skowronski J |title=Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling. |journal=EMBO J. |volume=16 |issue= 4 |pages= 673–84 |year= 1997 |pmid= 9049297 |doi= 10.1093/emboj/16.4.673
*cite journal | author=Vance BA, Bennett MJ, Ward Y, "et al." |title=Distinct but dispensable N-glycosylation of human CD69 proteins. |journal=Arch. Biochem. Biophys. |volume=368 |issue= 2 |pages= 214–20 |year= 1999 |pmid= 10441371 |doi= 10.1006/abbi.1999.1322
*cite journal | author=Blázquez MV, Macho A, Ortiz C, "et al." |title=Extracellular HIV type 1 Tat protein induces CD69 expression through NF-kappaB activation: possible correlation with cell surface Tat-binding proteins. |journal=AIDS Res. Hum. Retroviruses |volume=15 |issue= 13 |pages= 1209–18 |year= 1999 |pmid= 10480634 |doi= 10.1089/088922299310304
*cite journal | author=Llera AS, Viedma F, Sánchez-Madrid F, Tormo J |title=Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69. |journal=J. Biol. Chem. |volume=276 |issue= 10 |pages= 7312–9 |year= 2001 |pmid= 11036086 |doi= 10.1074/jbc.M008573200
*cite journal | author=Natarajan K, Sawicki MW, Margulies DH, Mariuzza RA |title=Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. |journal=Biochemistry |volume=39 |issue= 48 |pages= 14779–86 |year= 2001 |pmid= 11101293 |doi=
*cite journal | author=Liu X, Schrager JA, Lange GD, Marsh JW |title=HIV Nef-mediated cellular phenotypes are differentially expressed as a function of intracellular Nef concentrations. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32763–70 |year= 2001 |pmid= 11438519 |doi= 10.1074/jbc.M101025200
*cite journal | author=Diament D, Brunialti MK, Romero EC, "et al." |title=Peripheral blood mononuclear cell activation induced by Leptospira interrogans glycolipoprotein. |journal=Infect. Immun. |volume=70 |issue= 4 |pages= 1677–83 |year= 2002 |pmid= 11895929 |doi=
*cite journal | author=Yoshimura C, Yamaguchi M, Iikura M, "et al." |title=Activation markers of human basophils: CD69 expression is strongly and preferentially induced by IL-3. |journal=J. Allergy Clin. Immunol. |volume=109 |issue= 5 |pages= 817–23 |year= 2002 |pmid= 11994706 |doi=
*cite journal | author=Pisegna S, Zingoni A, Pirozzi G, "et al." |title=Src-dependent Syk activation controls CD69-mediated signaling and function on human NK cells. |journal=J. Immunol. |volume=169 |issue= 1 |pages= 68–74 |year= 2002 |pmid= 12077230 |doi=
*cite journal | author=Liu CC, Huang KJ, Lin YS, "et al." |title=Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection. |journal=J. Med. Virol. |volume=68 |issue= 2 |pages= 241–52 |year= 2002 |pmid= 12210415 |doi= 10.1002/jmv.10198
*cite journal | author=Foerster M, Haefner D, Kroegel C |title=Bcl-2-mediated regulation of CD69-induced apoptosis of human eosinophils: identification and characterization of a novel receptor-induced mechanism and relationship to CD95-transduced signalling. |journal=Scand. J. Immunol. |volume=56 |issue= 4 |pages= 417–28 |year= 2002 |pmid= 12234263 |doi=
*cite journal | author=Weigel G, Griesmacher A, Karimi A, "et al." |title=Effect of mycophenolate mofetil therapy on lymphocyte activation in heart transplant recipients. |journal=J. Heart Lung Transplant. |volume=21 |issue= 10 |pages= 1074–9 |year= 2003 |pmid= 12398872 |doi=

External links


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