EIF4G2


EIF4G2

Eukaryotic translation initiation factor 4 gamma, 2, also known as EIF4G2, is a human gene.

PBB_Summary
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summary_text = Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.cite web | title = Entrez Gene: EIF4G2 eukaryotic translation initiation factor 4 gamma, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1982| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Shaughnessy JD, Jenkins NA, Copeland NG |title=cDNA cloning, expression analysis, and chromosomal localization of a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G. |journal=Genomics |volume=39 |issue= 2 |pages= 192–7 |year= 1997 |pmid= 9027506 |doi= 10.1006/geno.1996.4502
*cite journal | author=Levy-Strumpf N, Deiss LP, Berissi H, Kimchi A |title=DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. |journal=Mol. Cell. Biol. |volume=17 |issue= 3 |pages= 1615–25 |year= 1997 |pmid= 9032289 |doi=
*cite journal | author=Imataka H, Olsen HS, Sonenberg N |title=A new translational regulator with homology to eukaryotic translation initiation factor 4G. |journal=EMBO J. |volume=16 |issue= 4 |pages= 817–25 |year= 1997 |pmid= 9049310 |doi= 10.1093/emboj/16.4.817
*cite journal | author=Imataka H, Sonenberg N |title=Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 6940–7 |year= 1997 |pmid= 9372926 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Pyronnet S, Imataka H, Gingras AC, "et al." |title=Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. |journal=EMBO J. |volume=18 |issue= 1 |pages= 270–9 |year= 1999 |pmid= 9878069 |doi= 10.1093/emboj/18.1.270
*cite journal | author=Marcotrigiano J, Gingras AC, Sonenberg N, Burley SK |title=Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. |journal=Mol. Cell |volume=3 |issue= 6 |pages= 707–16 |year= 1999 |pmid= 10394359 |doi=
*cite journal | author=Henis-Korenblit S, Strumpf NL, Goldstaub D, Kimchi A |title=A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation. |journal=Mol. Cell. Biol. |volume=20 |issue= 2 |pages= 496–506 |year= 2000 |pmid= 10611228 |doi=
*cite journal | author=Marcotrigiano J, Lomakin IB, Sonenberg N, "et al." |title=A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. |journal=Mol. Cell |volume=7 |issue= 1 |pages= 193–203 |year= 2001 |pmid= 11172724 |doi=
*cite journal | author=Marissen WE, Gradi A, Sonenberg N, Lloyd RE |title=Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis. |journal=Cell Death Differ. |volume=7 |issue= 12 |pages= 1234–43 |year= 2001 |pmid= 11175261 |doi= 10.1038/sj.cdd.4400750
*cite journal | author=Asano K, Shalev A, Phan L, "et al." |title=Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2326–37 |year= 2001 |pmid= 11331597 |doi= 10.1093/emboj/20.9.2326
*cite journal | author=Pyronnet S, Dostie J, Sonenberg N |title=Suppression of cap-dependent translation in mitosis. |journal=Genes Dev. |volume=15 |issue= 16 |pages= 2083–93 |year= 2001 |pmid= 11511540 |doi= 10.1101/gad.889201
*cite journal | author=Henis-Korenblit S, Shani G, Sines T, "et al." |title=The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 8 |pages= 5400–5 |year= 2002 |pmid= 11943866 |doi= 10.1073/pnas.082102499
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Perales C, Carrasco L, Ventoso I |title=Cleavage of eIF4G by HIV-1 protease: effects on translation. |journal=FEBS Lett. |volume=533 |issue= 1-3 |pages= 89–94 |year= 2003 |pmid= 12505164 |doi=
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Li Z, Hu CY, Mo BQ, "et al." |title= [Effect of beta-carotene on gene expression of breast cancer cells] |journal=Ai Zheng |volume=22 |issue= 4 |pages= 380–4 |year= 2003 |pmid= 12703993 |doi=
*cite journal | author=Qin H, Raught B, Sonenberg N, "et al." |title=Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 48570–9 |year= 2004 |pmid= 14507913 |doi= 10.1074/jbc.M308781200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

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