Eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein), also known as EEF1D, is a human gene.

section_title =
summary_text = This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and thus it represses the translation of host-cell, but not HIV-1, mRNAs. Several alternatively spliced transcript variants have been found for this gene, however, the full length nature of only two variants has been determined.cite web | title = Entrez Gene: EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Venema RC, Peters HI, Traugh JA |title=Phosphorylation of elongation factor 1 (EF-1) and valyl-tRNA synthetase by protein kinase C and stimulation of EF-1 activity. |journal=J. Biol. Chem. |volume=266 |issue= 19 |pages= 12574–80 |year= 1991 |pmid= 2061327 |doi=
*cite journal | author=van Damme HT, Amons R, Karssies R, "et al." |title=Elongation factor 1 beta of artemia: localization of functional sites and homology to elongation factor 1 delta. |journal=Biochim. Biophys. Acta |volume=1050 |issue= 1-3 |pages= 241–7 |year= 1990 |pmid= 2207149 |doi=
*cite journal | author=Bec G, Kerjan P, Zha XD, Waller JP |title=Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1. |journal=J. Biol. Chem. |volume=264 |issue= 35 |pages= 21131–7 |year= 1990 |pmid= 2556394 |doi=
*cite journal | author=Motorin YuA , Wolfson AD, Orlovsky AF, Gladilin KL |title=Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor. |journal=FEBS Lett. |volume=238 |issue= 2 |pages= 262–4 |year= 1988 |pmid= 3169261 |doi=
*cite journal | author=Mulner-Lorillon O, Minella O, Cormier P, "et al." |title=Elongation factor EF-1 delta, a new target for maturation-promoting factor in Xenopus oocytes. |journal=J. Biol. Chem. |volume=269 |issue= 31 |pages= 20201–7 |year= 1994 |pmid= 8051108 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Bec G, Kerjan P, Waller JP |title=Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 2086–92 |year= 1994 |pmid= 8294461 |doi=
*cite journal | author=Sanders J, Raggiaschi R, Morales J, Möller W |title=The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta. |journal=Biochim. Biophys. Acta |volume=1174 |issue= 1 |pages= 87–90 |year= 1993 |pmid= 8334168 |doi=
*cite journal | author=Sanders J, Brandsma M, Janssen GM, "et al." |title=Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum. |journal=J. Cell. Sci. |volume=109 ( Pt 5) |issue= |pages= 1113–7 |year= 1996 |pmid= 8743958 |doi=
*cite journal | author=Chang YW, Traugh JA |title=Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation. |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28252–7 |year= 1997 |pmid= 9353277 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Sheu GT, Traugh JA |title=Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli. Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 33290–7 |year= 1998 |pmid= 9407120 |doi=
*cite journal | author=Xiao H, Neuveut C, Benkirane M, Jeang KT |title=Interaction of the second coding exon of Tat with human EF-1 delta delineates a mechanism for HIV-1-mediated shut-off of host mRNA translation. |journal=Biochem. Biophys. Res. Commun. |volume=244 |issue= 2 |pages= 384–9 |year= 1998 |pmid= 9514931 |doi= 10.1006/bbrc.1998.8274
*cite journal | author=Kolettas E, Lymboura M, Khazaie K, Luqmani Y |title=Modulation of elongation factor-1 delta (EF-1 delta) expression by oncogenes in human epithelial cells. |journal=Anticancer Res. |volume=18 |issue= 1A |pages= 385–92 |year= 1998 |pmid= 9568107 |doi=
*cite journal | author=Scanlan MJ, Chen YT, Williamson B, "et al." |title=Characterization of human colon cancer antigens recognized by autologous antibodies. |journal=Int. J. Cancer |volume=76 |issue= 5 |pages= 652–8 |year= 1998 |pmid= 9610721 |doi=
*cite journal | author=Chacko G, Ling Q, Hajjar KA |title=Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta. |journal=J. Biol. Chem. |volume=273 |issue= 31 |pages= 19840–6 |year= 1998 |pmid= 9677419 |doi=
*cite journal | author=Sheu GT, Traugh JA |title=A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII. |journal=Mol. Cell. Biochem. |volume=191 |issue= 1-2 |pages= 181–6 |year= 1999 |pmid= 10094407 |doi=
*cite journal | author=Furusawa T, Moribe H, Kondoh H, Higashi Y |title=Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1. |journal=Mol. Cell. Biol. |volume=19 |issue= 12 |pages= 8581–90 |year= 2000 |pmid= 10567582 |doi=
*cite journal | author=Sang Lee J, Gyu Park S, Park H, "et al." |title=Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex. |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 1 |pages= 158–64 |year= 2002 |pmid= 11829477 |doi= 10.1006/bbrc.2002.6398
*cite journal | author=Lei YX, Chen JK, Wu ZL |title=Blocking the translation elongation factor-1 delta with its antisense mRNA results in a significant reversal of its oncogenic potential. |journal=Teratog., Carcinog. Mutagen. |volume=22 |issue= 5 |pages= 377–83 |year= 2002 |pmid= 12210501 |doi= 10.1002/tcm.10034

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