Pyrroline-5-carboxylate reductase

Pyrroline-5-carboxylate reductase

In enzymology, a pyrroline-5-carboxylate reductase (EC number| is an enzyme that catalyzes the chemical reaction

:L-proline + NAD(P)+ ightleftharpoons 1-pyrroline-5-carboxylate + NAD(P)H + H+

The 3 substrates of this enzyme are L-proline, NAD+, and NADP+, whereas its 4 products are 1-pyrroline-5-carboxylate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-proline:NAD(P)+ 5-oxidoreductase. Other names in common use include proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, and L-proline-NAD(P)+ 5-oxidoreductase. This enzyme participates in arginine and proline metabolism.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2AHR, PDB link|2GER, PDB link|2GR9, PDB link|2GRA, and PDB link|2IZZ.



External links

::"The CAS registry number for this enzyme class is CAS registry|9029-17-8."

Gene Ontology (GO) codes

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  • List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia

  • proline — Pyrrolidine 2 carboxylic acid; the l isomer is found in proteins, especially the collagens. SYN: pyrrolidine 2 carboxylate. p. aminopeptidase SYN: p. iminopeptidase. p. dehydrogenase SYN: pyrroline 2 carboxylate reductase, pyrroline 5 carboxylate …   Medical dictionary

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