N-methylalanine dehydrogenase

N-methylalanine dehydrogenase
N-methylalanine dehydrogenase
Identifiers
EC number 1.4.1.17
CAS number 56379-51-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N-methylalanine dehydrogenase (EC 1.4.1.17) is an enzyme that catalyzes the chemical reaction

N-methyl-L-alanine + H2O + NADP+ \rightleftharpoons pyruvate + methylamine + NADPH + H+

The 3 substrates of this enzyme are N-methyl-L-alanine, H2O, and NADP+, whereas its 4 products are pyruvate, methylamine, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating).

References

  • Lin MC, Wagner C (1975). "Purification and characterization of N-methylalanine dehydrogenase". J. Biol. Chem. 250 (10): 3746–51. PMID 236301. 
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