Nitroalkane oxidase

nitroethane oxidase
Identifiers
EC number	1.7.3.1
CAS number	9029-36-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a nitroalkane oxidase (EC 1.7.3.1) is an enzyme that catalyzes the chemical reaction

a nitroalkane + H₂O + O₂ $\rightleftharpoons$ an aldehyde or ketone + nitrite + H₂O₂

The 3 substrates of this enzyme are nitroalkane, H₂O, and O₂, whereas its 4 products are aldehyde, ketone, nitrite, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with oxygen as acceptor. The systematic name of this enzyme class is nitroalkane:oxygen oxidoreductase. Other names in common use include nitroethane oxidase, NAO, and nitroethane:oxygen oxidoreductase. This enzyme participates in nitrogen metabolism.

References

• LITTLE HN (1951). "Oxidation of nitroethane by extracts from Neurospora". J. Biol. Chem. 193 (1): 347–58. PMID 14907722. 
• Kido T, Hashizume K, Soda K (1978). "Purification and properties of nitroalkane oxidase from Fusarium oxysporum". J. Bacteriol. 133 (1): 53–8. PMC 221975. PMID 22538. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=221975. 
• Daubner SC, Gadda G, Valley MP, Fitzpatrick PF (2002). "Cloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily". Proc. Natl. Acad. Sci. U. S. A. 99 (5): 2702–7. doi:10.1073/pnas.052527799. PMC 122411. PMID 11867731. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=122411. 
• Fitzpatrick PF, Orville AM, Nagpal A, Valley MP (2005). "Nitroalkane oxidase, a carbanion-forming flavoprotein homologous to acyl-CoA dehydrogenase". Arch. Biochem. Biophys. 433 (1): 157–65. doi:10.1016/j.abb.2004.08.021. PMID 15581574. 
• Valley MP, Tichy SE, Fitzpatrick PF (2005). "Establishing the kinetic competency of the cationic imine intermediate in nitroalkane oxidase". J. Am. Chem. Soc. 127 (7): 2062–6. doi:10.1021/ja043542f. PMC 1630679. PMID 15713081. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1630679. 

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