NADPH dehydrogenase

NADPH dehydrogenase
NADPH dehydrogenase
EC number
CAS number 9001-68-7
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a NADPH dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

NADPH + H+ + acceptor \rightleftharpoons NADP+ + reduced acceptor

The 3 substrates of this enzyme are NADPH, H+, and acceptor, whereas its two products are NADP+ and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is NADPH:acceptor oxidoreductase. Other names in common use include NADPH2 diaphorase, NADPH diaphorase, OYE, diaphorase, dihydronicotinamide adenine dinucleotide phosphate dehydrogenase, NADPH-dehydrogenase, NADPH-diaphorase, NADPH2-dehydrogenase, old yellow enzyme, reduced nicotinamide adenine dinucleotide phosphate dehydrogenase, TPNH dehydrogenase, TPNH-diaphorase, triphosphopyridine diaphorase, triphosphopyridine nucleotide diaphorase, NADPH2 dehydrogenase, and NADPH:(acceptor) oxidoreductase. It has 2 cofactors: FAD, and FMN.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1BWK, 1BWL, 1HDO, 1HE2, 1HE3, 1HE4, 1HE5, 1K02, 1K03, 1OYA, 1OYB, and 1OYC.


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