Cell division cycle 6 homolog (S. cerevisiae), also known as CDC6, is a human gene.

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summary_text = The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cycle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cycle is regulated through its phosphorylation by Cyclin-dependent kinases. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.cite web | title = Entrez Gene: CDC6 cell division cycle 6 homolog (S. cerevisiae)| url =| accessdate = ]

ee also

*Cdc6 homolog in Saccharomyces cerevisiae


Further reading

citations =
*cite journal | author=Williams RS, Shohet RV, Stillman B |title=A human protein related to yeast Cdc6p. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 1 |pages= 142–7 |year= 1997 |pmid= 8990175 |doi=
*cite journal | author=Yan Z, DeGregori J, Shohet R, "et al." |title=Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 7 |pages= 3603–8 |year= 1998 |pmid= 9520412 |doi=
*cite journal | author=Saha P, Chen J, Thome KC, "et al." |title=Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2758–67 |year= 1998 |pmid= 9566895 |doi=
*cite journal | author=Hateboer G, Wobst A, Petersen BO, "et al." |title=Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6679–97 |year= 1998 |pmid= 9774682 |doi=
*cite journal | author=Ohtani K, Tsujimoto A, Ikeda M, Nakamura M |title=Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F. |journal=Oncogene |volume=17 |issue= 14 |pages= 1777–85 |year= 1998 |pmid= 9778043 |doi= 10.1038/sj.onc.1202105
*cite journal | author=Stoeber K, Mills AD, Kubota Y, "et al." |title=Cdc6 protein causes premature entry into S phase in a mammalian cell-free system. |journal=EMBO J. |volume=17 |issue= 24 |pages= 7219–29 |year= 1999 |pmid= 9857179 |doi= 10.1093/emboj/17.24.7219
*cite journal | author=Petersen BO, Lukas J, Sørensen CS, "et al." |title=Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. |journal=EMBO J. |volume=18 |issue= 2 |pages= 396–410 |year= 1999 |pmid= 9889196 |doi= 10.1093/emboj/18.2.396
*cite journal | author=van Hannen EJ, Zwart G, van Agterveld MP, "et al." |title=Changes in bacterial and eukaryotic community structure after mass lysis of filamentous cyanobacteria associated with viruses. |journal=Appl. Environ. Microbiol. |volume=65 |issue= 2 |pages= 795–801 |year= 1999 |pmid= 9925618 |doi=
*cite journal | author=Takei Y, Yamamoto K, Tsujimoto G |title=Identification of the sequence responsible for the nuclear localization of human Cdc6. |journal=FEBS Lett. |volume=447 |issue= 2-3 |pages= 292–6 |year= 1999 |pmid= 10214964 |doi=
*cite journal | author=Jiang W, Wells NJ, Hunter T |title=Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6193–8 |year= 1999 |pmid= 10339564 |doi=
*cite journal | author=Fujita M, Yamada C, Goto H, "et al." |title=Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation. |journal=J. Biol. Chem. |volume=274 |issue= 36 |pages= 25927–32 |year= 1999 |pmid= 10464337 |doi=
*cite journal | author=Yan Z, Fedorov SA, Mumby MC, Williams RS |title=PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1021–9 |year= 2000 |pmid= 10629059 |doi=
*cite journal | author=Takahashi Y, Rayman JB, Dynlacht BD |title=Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. |journal=Genes Dev. |volume=14 |issue= 7 |pages= 804–16 |year= 2000 |pmid= 10766737 |doi=
*cite journal | author=Takayama M, Taira T, Iguchi-Ariga SM, Ariga H |title=CDC6 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc/Max complex. |journal=FEBS Lett. |volume=477 |issue= 1-2 |pages= 43–8 |year= 2000 |pmid= 10899308 |doi=
*cite journal | author=Petersen BO, Wagener C, Marinoni F, "et al." |title=Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. |journal=Genes Dev. |volume=14 |issue= 18 |pages= 2330–43 |year= 2000 |pmid= 10995389 |doi=
*cite journal | author=Méndez J, Stillman B |title=Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. |journal=Mol. Cell. Biol. |volume=20 |issue= 22 |pages= 8602–12 |year= 2000 |pmid= 11046155 |doi=
*cite journal | author=Delmolino LM, Saha P, Dutta A |title=Multiple mechanisms regulate subcellular localization of human CDC6. |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 26947–54 |year= 2001 |pmid= 11346650 |doi= 10.1074/jbc.M101870200
*cite journal | author=Fujita M, Ishimi Y, Nakamura H, "et al." |title=Nuclear organization of DNA replication initiation proteins in mammalian cells. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10354–61 |year= 2002 |pmid= 11779870 |doi= 10.1074/jbc.M111398200
*cite journal | author=Biermann E, Baack M, Kreitz S, Knippers R |title=Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle. |journal=Eur. J. Biochem. |volume=269 |issue= 3 |pages= 1040–6 |year= 2002 |pmid= 11846807 |doi=
*cite journal | author=Robles LD, Frost AR, Davila M, "et al." |title=Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25431–8 |year= 2002 |pmid= 12006585 |doi= 10.1074/jbc.M201199200

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