EDG1

EDG1 (endothelial differentiation gene 1) is a human gene which encodes a G-protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₁.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.cite web | title = Entrez Gene: EDG1 endothelial differentiation, sphingolipid G-protein-coupled receptor, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1901| accessdate = ]

ee also

* Lysophospholipid receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Spiegel S |title=Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. |journal=Ann. N. Y. Acad. Sci. |volume=905 |issue= |pages= 54–60 |year= 2000 |pmid= 10818441 |doi=
*cite journal | author=Igarashi Y |title= [Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 4 Suppl |pages= 476–9 |year= 2002 |pmid= 11915345 |doi=
*cite journal | author=Takuwa Y |title= [Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 4 Suppl |pages= 496–502 |year= 2002 |pmid= 11915348 |doi=
*cite journal | author=Takuwa Y, Takuwa N, Sugimoto N |title=The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities. |journal=J. Biochem. |volume=131 |issue= 6 |pages= 767–71 |year= 2003 |pmid= 12038970 |doi=
*cite journal | author=Hla T, Maciag T |title=An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. |journal=J. Biol. Chem. |volume=265 |issue= 16 |pages= 9308–13 |year= 1990 |pmid= 2160972 |doi=
*cite journal | author=Lee MJ, Evans M, Hla T |title=The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11272–9 |year= 1996 |pmid= 8626678 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=An S, Bleu T, Huang W, "et al." |title=Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. |journal=FEBS Lett. |volume=417 |issue= 3 |pages= 279–82 |year= 1998 |pmid= 9409733 |doi=
*cite journal | author=Lee MJ, Van Brocklyn JR, Thangada S, "et al." |title=Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. |journal=Science |volume=279 |issue= 5356 |pages= 1552–5 |year= 1998 |pmid= 9488656 |doi=
*cite journal | author=Lee MJ, Thangada S, Liu CH, "et al." |title=Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 22105–12 |year= 1998 |pmid= 9705355 |doi=
*cite journal | author=Ancellin N, Hla T |title=Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 18997–9002 |year= 1999 |pmid= 10383399 |doi=
*cite journal | author=Windh RT, Lee MJ, Hla T, "et al." |title=Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 27351–8 |year= 1999 |pmid= 10488065 |doi=
*cite journal | author=Lee MJ, Thangada S, Claffey KP, "et al." |title=Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. |journal=Cell |volume=99 |issue= 3 |pages= 301–12 |year= 1999 |pmid= 10555146 |doi=
*cite journal | author=Igarashi J, Michel T |title=Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32363–70 |year= 2000 |pmid= 10921915 |doi= 10.1074/jbc.M003075200
*cite journal | author=Parrill AL, Wang D, Bautista DL, "et al." |title=Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39379–84 |year= 2001 |pmid= 10982820 |doi= 10.1074/jbc.M007680200
*cite journal | author=Liu Y, Wada R, Yamashita T, "et al." |title=Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. |journal=J. Clin. Invest. |volume=106 |issue= 8 |pages= 951–61 |year= 2000 |pmid= 11032855 |doi=
*cite journal | author=Murphy WJ, Eizirik E, Johnson WE, "et al." |title=Molecular phylogenetics and the origins of placental mammals. |journal=Nature |volume=409 |issue= 6820 |pages= 614–8 |year= 2001 |pmid= 11214319 |doi= 10.1038/35054550
*cite journal | author=Hobson JP, Rosenfeldt HM, Barak LS, "et al." |title=Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. |journal=Science |volume=291 |issue= 5509 |pages= 1800–3 |year= 2001 |pmid= 11230698 |doi= 10.1126/science.1057559
*cite journal | author=Lee MJ, Thangada S, Paik JH, "et al." |title=Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. |journal=Mol. Cell |volume=8 |issue= 3 |pages= 693–704 |year= 2001 |pmid= 11583630 |doi=

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1338 IUPHAR GPCR Database - Lysophospholipid receptors]
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