Formyltetrahydrofolate dehydrogenase

Formyltetrahydrofolate dehydrogenase

In enzymology, a formyltetrahydrofolate dehydrogenase (EC number|1.5.1.6) is an enzyme that catalyzes the chemical reaction

:10-formyltetrahydrofolate + NADP+ + H2O ightleftharpoons tetrahydrofolate + CO2 + NADPH + H+

The 3 substrates of this enzyme are 10-formyltetrahydrofolate, NADP+, and H2O, whereas its 4 products are tetrahydrofolate, CO2, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 10-formyltetrahydrofolate:NADP+ oxidoreductase. Other names in common use include 10-formyl tetrahydrofolate:NADP oxidoreductase, 10-formyl-H2PtGlu:NADP oxidoreductase, 10-formyl-H4folate dehydrogenase, N10-formyltetrahydrofolate dehydrogenase, and 10-formyltetrahydrofolate dehydrogenase. This enzyme participates in one carbon pool by folate.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1S3I, PDB link|2BW0, PDB link|2CFI, PDB link|2CQ8, PDB link|2O2P, PDB link|2O2Q, and PDB link|2O2R.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37256-25-0."

Gene Ontology (GO) codes


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