PDGFA


PDGFA
Platelet-derived growth factor alpha polypeptide
Identifiers
Symbols PDGFA; PDGF-A; PDGF1
External IDs OMIM173430 MGI97527 HomoloGene32055 GeneCards: PDGFA Gene
RNA expression pattern
PBB GE PDGFA 205463 s at tn.png
PBB GE PDGFA 216867 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5154 18590
Ensembl ENSG00000197461 ENSMUSG00000025856
UniProt P04085 Q7TPH7
RefSeq (mRNA) NM_002607.5 NM_008808.3
RefSeq (protein) NP_002598.4 NP_032834.1
Location (UCSC) Chr 7:
0.54 – 0.56 Mb
Chr 5:
139.45 – 139.47 Mb
PubMed search [1] [2]

Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene.[1][2]

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.[3]

References

  1. ^ Stenman G, Rorsman F, Huebner K, Betsholtz C (Sep 1992). "The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22". Cytogenet Cell Genet 60 (3–4): 206–7. doi:10.1159/000133337. PMID 1505216. 
  2. ^ Matsui T, Heidaran M, Miki T, Popescu N, La Rochelle W, Kraus M, Pierce J, Aaronson S (Mar 1989). "Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes". Science 243 (4892): 800–4. doi:10.1126/science.2536956. PMID 2536956. 
  3. ^ "Entrez Gene: PDGFA platelet-derived growth factor alpha polypeptide". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5154. 

Further reading



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