Cob(II)yrinic acid a,c-diamide reductase

cob(II)yrinic acid a,c-diamide reductase
Identifiers
EC number	1.16.8.1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a cob(II)yrinic acid a,c-diamide reductase (EC 1.16.8.1) is an enzyme that catalyzes the chemical reaction

2 cob(I)yrinic acid a,c-diamide + FMN + 2 H⁺ $\rightleftharpoons$ 2 cob(II)yrinic acid a,c-diamide + FMNH₂

The 3 substrates of this enzyme are cob(I)yrinic acid a,c-diamide, FMN, and H⁺, whereas its two products are cob(II)yrinic acid a,c-diamide and FMNH2.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with a flavin as acceptor. The systematic name of this enzyme class is cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase. This enzyme is also called cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect). This enzyme participates in porphyrin and chlorophyll metabolism.

References

• Blanche F, Maton L, Debussche L, Thibaut D (1992). "Purification and characterization of Cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans". J. Bacteriol. 174 (22): 7452–4. PMC 207442. PMID 1429467. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=207442. 
• Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B₁₂)". Nat. Prod. Rep. 19 (4): 390–412. doi:10.1039/b108967f. PMID 12195810. 

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