Telomeric repeat binding factor 2, also known as TERF2, is a human gene.

section_title =
summary_text = This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.cite web | title = Entrez Gene: TERF2 telomeric repeat binding factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7014| accessdate = ]


citations =
*cite journal | author=Bilaud T, Koering CE, Binet-Brasselet E, "et al." |title=The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human. |journal=Nucleic Acids Res. |volume=24 |issue= 7 |pages= 1294–303 |year= 1996 |pmid= 8614633 |doi=
*cite journal | author=Broccoli D, Smogorzewska A, Chong L, de Lange T |title=Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. |journal=Nat. Genet. |volume=17 |issue= 2 |pages= 231–5 |year= 1997 |pmid= 9326950 |doi= 10.1038/ng1097-231
*cite journal | author=Bilaud T, Brun C, Ancelin K, "et al." |title=Telomeric localization of TRF2, a novel human telobox protein. |journal=Nat. Genet. |volume=17 |issue= 2 |pages= 236–9 |year= 1997 |pmid= 9326951 |doi= 10.1038/ng1097-236
*cite journal | author=van Steensel B, Smogorzewska A, de Lange T |title=TRF2 protects human telomeres from end-to-end fusions. |journal=Cell |volume=92 |issue= 3 |pages= 401–13 |year= 1998 |pmid= 9476899 |doi=
*cite journal | author=Sakaguchi AY, Padalecki SS, Mattern V, "et al." |title=Chromosomal sublocalization of the transcribed human telomere repeat binding factor 2 gene and comparative mapping in the mouse. |journal=Somat. Cell Mol. Genet. |volume=24 |issue= 3 |pages= 157–63 |year= 1999 |pmid= 10226653 |doi=
*cite journal | author=Griffith JD, Comeau L, Rosenfield S, "et al." |title=Mammalian telomeres end in a large duplex loop. |journal=Cell |volume=97 |issue= 4 |pages= 503–14 |year= 1999 |pmid= 10338214 |doi=
*cite journal | author=Teichmann M, Wang Z, Martinez E, "et al." |title=Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 24 |pages= 13720–5 |year= 2000 |pmid= 10570139 |doi=
*cite journal | author=Smogorzewska A, van Steensel B, Bianchi A, "et al." |title=Control of human telomere length by TRF1 and TRF2. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1659–68 |year= 2000 |pmid= 10669743 |doi=
*cite journal | author=Li B, Oestreich S, de Lange T |title=Identification of human Rap1: implications for telomere evolution. |journal=Cell |volume=101 |issue= 5 |pages= 471–83 |year= 2000 |pmid= 10850490 |doi=
*cite journal | author=Zhu XD, Küster B, Mann M, "et al." |title=Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. |journal=Nat. Genet. |volume=25 |issue= 3 |pages= 347–52 |year= 2000 |pmid= 10888888 |doi= 10.1038/77139
*cite journal | author=Song K, Jung D, Jung Y, "et al." |title=Interaction of human Ku70 with TRF2. |journal=FEBS Lett. |volume=481 |issue= 1 |pages= 81–5 |year= 2000 |pmid= 10984620 |doi=
*cite journal | author=Song K, Jung Y, Jung D, Lee I |title=Human Ku70 interacts with heterochromatin protein 1alpha. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 8321–7 |year= 2001 |pmid= 11112778 |doi= 10.1074/jbc.M008779200
*cite journal | author=Fairall L, Chapman L, Moss H, "et al." |title=Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. |journal=Mol. Cell |volume=8 |issue= 2 |pages= 351–61 |year= 2001 |pmid= 11545737 |doi=
*cite journal | author=Bailey SM, Cornforth MN, Kurimasa A, "et al." |title=Strand-specific postreplicative processing of mammalian telomeres. |journal=Science |volume=293 |issue= 5539 |pages= 2462–5 |year= 2001 |pmid= 11577237 |doi= 10.1126/science.1062560
*cite journal | author=Karlseder J, Smogorzewska A, de Lange T |title=Senescence induced by altered telomere state, not telomere loss. |journal=Science |volume=295 |issue= 5564 |pages= 2446–9 |year= 2002 |pmid= 11923537 |doi= 10.1126/science.1069523
*cite journal | author=Mignon-Ravix C, Depetris D, Delobel B, "et al." |title=A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins. |journal=Eur. J. Hum. Genet. |volume=10 |issue= 2 |pages= 107–12 |year= 2002 |pmid= 11938440 |doi= 10.1038/sj.ejhg.5200775
*cite journal | author=Ancelin K, Brunori M, Bauwens S, "et al." |title=Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. |journal=Mol. Cell. Biol. |volume=22 |issue= 10 |pages= 3474–87 |year= 2002 |pmid= 11971978 |doi=
*cite journal | author=Opresko PL, von Kobbe C, Laine JP, "et al." |title=Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 41110–9 |year= 2002 |pmid= 12181313 |doi= 10.1074/jbc.M205396200
*cite journal | author=Chagnon P, Michaud J, Mitchell G, "et al." |title=A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. |journal=Am. J. Hum. Genet. |volume=71 |issue= 6 |pages= 1443–9 |year= 2003 |pmid= 12417987 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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