Betaine-aldehyde dehydrogenase


Betaine-aldehyde dehydrogenase

In enzymology, a betaine-aldehyde dehydrogenase (EC number|1.2.1.8) is an enzyme that catalyzes the chemical reaction

:betaine aldehyde + NAD+ + H2O ightleftharpoons betaine + NADH + 2 H+

The 3 substrates of this enzyme are betaine aldehyde, NAD+, and H2O, whereas its 3 products are betaine, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is betaine-aldehyde:NAD+ oxidoreductase. Other names in common use include betaine aldehyde oxidase, BADH, betaine aldehyde dehydrogenase, and BetB. This enzyme participates in glycine, serine and threonine metabolism.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1A4S, PDB link|1BPW, PDB link|1WNB, and PDB link|1WND.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9028-90-4."

Gene Ontology (GO) codes


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