Aldehyde dehydrogenase (NAD(P)+)


Aldehyde dehydrogenase (NAD(P)+)

In enzymology, an aldehyde dehydrogenase [NAD(P)+] (EC number|1.2.1.5) is an enzyme that catalyzes the chemical reaction

:an aldehyde + NAD(P)+ + H2O ightleftharpoons an acid + NAD(P)H + H+

The 4 substrates of this enzyme are aldehyde, NAD+, NADP+, and H2O, whereas its 4 products are acid, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aldehyde:NAD(P)+ oxidoreductase. Other names in common use include aldehyde dehydrogenase [NAD(P)+] , and ALDH. This enzyme participates in 5 metabolic pathways: glycolysis / gluconeogenesis, histidine metabolism, tyrosine metabolism, phenylalanine metabolism, and metabolism of xenobiotics by cytochrome p450.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1AD3, PDB link|1EYY, PDB link|1EZ0, and PDB link|2AMF.

References

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* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
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External links

::"The CAS registry number for this enzyme class is CAS registry|9028-88-0."

Gene Ontology (GO) codes


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