- Aldehyde dehydrogenase (NAD+)
enzymology, an aldehyde dehydrogenase (NAD+) (EC number|220.127.116.11) is an enzymethat catalyzes the chemical reaction
:an aldehyde + NAD+ + H2O an acid + NADH + H+
This enzyme belongs to the family of
oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aldehyde:NAD+ oxidoreductase. Other names in common use include CoA-independent aldehyde dehydrogenase, m-methylbenzaldehyde dehydrogenase, NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked aldehyde dehydrogenase, propionaldehyde dehydrogenase, and aldehyde dehydrogenase (NAD). This enzyme participates in 17 metabolic pathways: glycolysis / gluconeogenesis, ascorbate and aldarate metabolism, fatty acid metabolism, bile acid biosynthesis, urea cycle and metabolism of amino groups, valine, leucine and isoleucine degradation, lysine degradation, histidine metabolism, tryptophan metabolism, beta-alanine metabolism, glycerolipid metabolism, pyruvate metabolism, 1,2-dichloroethane degradation, propanoate metabolism, 3-chloroacrylic acid degradation, butanoate metabolism, and limonene and pinene degradation.
As of late 2007, 23 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1A4Z, PDB link|1AG8, PDB link|1BXS, PDB link|1CW3, PDB link|1NZW, PDB link|1NZX, PDB link|1NZZ, PDB link|1O00, PDB link|1O01, PDB link|1O02, PDB link|1O04, PDB link|1O05, PDB link|1O9J, PDB link|1OF7, PDB link|1OM2, PDB link|1ZUM, PDB link|2J6L, PDB link|2ONM, PDB link|2ONN, PDB link|2ONO, PDB link|2ONP, PDB link|2V1S, and PDB link|2V1T.
* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
CAS registry numberfor this enzyme class is CAS registry|9028-86-8."
Gene Ontology (GO) codes
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