UCP3

Uncoupling protein 3 (mitochondrial, proton carrier), also known as UCP3, is a human gene.cite journal | author = Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB | title = UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue | journal = Biochem. Biophys. Res. Commun. | volume = 235 | issue = 1 | pages = 79–82 | year = 1997 | month = June | pmid = 9196039 | doi = 10.1006/bbrc.1997.6740 | url = ] cite journal | author = Boss O, Giacobino JP, Muzzin P | title = Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13 | journal = Genomics | volume = 47 | issue = 3 | pages = 425–6 | year = 1998 | month = February | pmid = 9480760 | doi = 10.1006/geno.1997.5135 | url = ]

Function

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H⁺/OH^- are not known.cite web | title = Entrez Gene: UCP3 uncoupling protein 3 (mitochondrial, proton carrier)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7352| accessdate = ]

tructure

UCPs contain the three homologous protein domains of MACPs.

Gene regulation

This gene has tissue-specific transcription initiation with other transcription initiation sites upstream of SM-1 (major skeletal muscle site). Chromosomal order is 5'-UCP3-UCP2-3'. Two splice variants have been found for this gene.

Disease association

Mutations in the UCP3 gene are associated with obesity.cite journal | author = Argyropoulos G, Brown AM, Willi SM, Zhu J, He Y, Reitman M, Gevao SM, Spruill I, Garvey WT | title = Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes | journal = J. Clin. Invest. | volume = 102 | issue = 7 | pages = 1345–51 | year = 1998 | month = October | pmid = 9769326 | pmc = 508981 | doi = 10.1172/JCI4115 | url = ] cite journal | author = Dalgaard LT, Sørensen TI, Drivsholm T, "et al" | title = A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population | journal = J. Clin. Endocrinol. Metab. | volume = 86 | issue = 3 | pages = 1398–402 | year = 2001 | month = March | pmid = 11238538 | doi = 10.1210/jc.86.3.1398 | url = ]

ee also

* Uncoupling protein

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ricquier D, Bouillaud F |title=The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. |journal=Biochem. J. |volume=345 Pt 2 |issue= |pages= 161–79 |year= 2000 |pmid= 10620491 |doi=10.1042/0264-6021:3450161
*cite journal | author=Muzzin P |title=The uncoupling proteins. |journal=Ann. Endocrinol. (Paris) |volume=63 |issue= 2 Pt 1 |pages= 106–10 |year= 2002 |pmid= 11994670 |doi=
*cite journal | author=Boss O, Samec S, Paoloni-Giacobino A, "et al." |title=Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. |journal=FEBS Lett. |volume=408 |issue= 1 |pages= 39–42 |year= 1997 |pmid= 9180264 |doi=10.1016/S0014-5793(97)00384-0
*cite journal | author=Vidal-Puig A, Solanes G, Grujic D, "et al." |title=UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 1 |pages= 79–82 |year= 1997 |pmid= 9196039 |doi= 10.1006/bbrc.1997.6740
*cite journal | author=Gong DW, He Y, Karas M, Reitman M |title=Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24129–32 |year= 1997 |pmid= 9305858 |doi=10.1074/jbc.272.39.24129
*cite journal | author=Solanes G, Vidal-Puig A, Grujic D, "et al." |title=The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25433–6 |year= 1997 |pmid= 9325252 |doi=10.1074/jbc.272.41.25433
*cite journal | author=Boss O, Giacobino JP, Muzzin P |title=Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13. |journal=Genomics |volume=47 |issue= 3 |pages= 425–6 |year= 1998 |pmid= 9480760 |doi= 10.1006/geno.1997.5135
*cite journal | author=Urhammer SA, Dalgaard LT, Sørensen TI, "et al." |title=Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity. |journal=Diabetologia |volume=41 |issue= 2 |pages= 241–4 |year= 1998 |pmid= 9498661 |doi=10.1007/s001250050897
*cite journal | author=Argyropoulos G, Brown AM, Willi SM, "et al." |title=Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. |journal=J. Clin. Invest. |volume=102 |issue= 7 |pages= 1345–51 |year= 1998 |pmid= 9769326 |doi=10.1172/JCI4115
*cite journal | author=Acín A, Rodriguez M, Rique H, "et al." |title=Cloning and characterization of the 5' flanking region of the human uncoupling protein 3 (UCP3) gene. |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 2 |pages= 278–83 |year= 1999 |pmid= 10329378 |doi=10.1006/bbrc.1999.0530
*cite journal | author=Vidal-Puig AJ, Grujic D, Zhang CY, "et al." |title=Energy metabolism in uncoupling protein 3 gene knockout mice. |journal=J. Biol. Chem. |volume=275 |issue= 21 |pages= 16258–66 |year= 2000 |pmid= 10748196 |doi= 10.1074/jbc.M910179199
*cite journal | author=Jezek P, Urbánková E |title=Specific sequence of motifs of mitochondrial uncoupling proteins. |journal=IUBMB Life |volume=49 |issue= 1 |pages= 63–70 |year= 2000 |pmid= 10772343 |doi=
*cite journal | author=Pierrat B, Ito M, Hinz W, "et al." |title=Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family. |journal=Eur. J. Biochem. |volume=267 |issue= 9 |pages= 2680–7 |year= 2000 |pmid= 10785390 |doi=10.1046/j.1432-1327.2000.01285.x
*cite journal | author=Clapham JC, Arch JR, Chapman H, "et al." |title=Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. |journal=Nature |volume=406 |issue= 6794 |pages= 415–8 |year= 2000 |pmid= 10935638 |doi= 10.1038/35019082
*cite journal | author=Esterbauer H, Oberkofler H, Krempler F, "et al." |title=The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents. |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 36394–9 |year= 2000 |pmid= 10958796 |doi= 10.1074/jbc.M005713200
*cite journal | author=Lanouette CM, Chagnon YC, Rice T, "et al." |title=Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study. |journal=J. Appl. Physiol. |volume=92 |issue= 3 |pages= 1111–8 |year= 2002 |pmid= 11842047 |doi= 10.1152/japplphysiol.00726.2001 | doi_brokendate=2008-10-03
*cite journal | author=Collins P, Bing C, McCulloch P, Williams G |title=Muscle UCP-3 mRNA levels are elevated in weight loss associated with gastrointestinal adenocarcinoma in humans. |journal=Br. J. Cancer |volume=86 |issue= 3 |pages= 372–5 |year= 2002 |pmid= 11875702 |doi= 10.1038/sj.bjc.6600074
*cite journal | author=Hu X, Murphy F, Karwautz A, "et al." |title=Analysis of microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa. |journal=Mol. Psychiatry |volume=7 |issue= 3 |pages= 276–7 |year= 2002 |pmid= 11920154 |doi= 10.1038/sj.mp.4001044

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes