Cadherin 5, type 2 or VE-cadherin (vascular epithelium) also known as CD144 (Cluster of Differentiation 144), is a type of cadherin. It is encoded by the human gene CDH5.

section_title =
summary_text = It is a classical cadherin from the cadherin superfamily and the gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.cite web | title = Entrez Gene: CDH5 cadherin 5, type 2, VE-cadherin (vascular epithelium)| url =| accessdate = ]


ee also

* Cluster of differentiation

Further reading

citations =
*cite journal | author=Lampugnani MG, Resnati M, Raiteri M, "et al." |title=A novel endothelial-specific membrane protein is a marker of cell-cell contacts. |journal=J. Cell Biol. |volume=118 |issue= 6 |pages= 1511–22 |year= 1992 |pmid= 1522121 |doi=
*cite journal | author=Suzuki S, Sano K, Tanihara H |title=Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. |journal=Cell Regul. |volume=2 |issue= 4 |pages= 261–70 |year= 1991 |pmid= 2059658 |doi=
*cite journal | author=Breviario F, Caveda L, Corada M, "et al." |title=Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=15 |issue= 8 |pages= 1229–39 |year= 1995 |pmid= 7627717 |doi=
*cite journal | author=Ali J, Liao F, Martens E, Muller WA |title=Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion. |journal=Microcirculation (New York, N.Y. : 1994) |volume=4 |issue= 2 |pages= 267–77 |year= 1997 |pmid= 9219219 |doi=
*cite journal | author=Lampugnani MG, Corada M, Andriopoulou P, "et al." |title=Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells. |journal=J. Cell. Sci. |volume=110 ( Pt 17) |issue= |pages= 2065–77 |year= 1997 |pmid= 9378757 |doi=
*cite journal | author=Lewalle JM, Bajou K, Desreux J, "et al." |title=Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro. |journal=Exp. Cell Res. |volume=237 |issue= 2 |pages= 347–56 |year= 1998 |pmid= 9434630 |doi= 10.1006/excr.1997.3799
*cite journal | author=Kremmidiotis G, Baker E, Crawford J, "et al." |title=Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. |journal=Genomics |volume=49 |issue= 3 |pages= 467–71 |year= 1998 |pmid= 9615235 |doi= 10.1006/geno.1998.5281
*cite journal | author=Kowalczyk AP, Navarro P, Dejana E, "et al." |title=VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions. |journal=J. Cell. Sci. |volume=111 ( Pt 20) |issue= |pages= 3045–57 |year= 1998 |pmid= 9739078 |doi=
*cite journal | author=Kawashima M, Kitagawa M |title=An immunohistochemical study of cadherin 5 (VE-cadherin) in vascular endothelial cells in placentas with gestosis. |journal=J. Obstet. Gynaecol. Res. |volume=24 |issue= 6 |pages= 375–84 |year= 1999 |pmid= 10063232 |doi=
*cite journal | author=Carmeliet P, Lampugnani MG, Moons L, "et al." |title=Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. |journal=Cell |volume=98 |issue= 2 |pages= 147–57 |year= 1999 |pmid= 10428027 |doi=
*cite journal | author=Ukropec JA, Hollinger MK, Salva SM, Woolkalis MJ |title=SHP2 association with VE-cadherin complexes in human endothelial cells is regulated by thrombin. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5983–6 |year= 2000 |pmid= 10681592 |doi=
*cite journal | author=Shimoyama Y, Tsujimoto G, Kitajima M, Natori M |title=Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. |journal=Biochem. J. |volume=349 |issue= Pt 1 |pages= 159–67 |year= 2001 |pmid= 10861224 |doi=
*cite journal | author=Shaw SK, Bamba PS, Perkins BN, Luscinskas FW |title=Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium. |journal=J. Immunol. |volume=167 |issue= 4 |pages= 2323–30 |year= 2001 |pmid= 11490021 |doi=
*cite journal | author=van Buul JD, Voermans C, van den Berg V, "et al." |title=Migration of human hematopoietic progenitor cells across bone marrow endothelium is regulated by vascular endothelial cadherin. |journal=J. Immunol. |volume=168 |issue= 2 |pages= 588–96 |year= 2002 |pmid= 11777950 |doi=
*cite journal | author=Ferber A, Yaen C, Sarmiento E, Martinez J |title=An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation. |journal=Exp. Cell Res. |volume=274 |issue= 1 |pages= 35–44 |year= 2002 |pmid= 11855855 |doi= 10.1006/excr.2001.5436
*cite journal | author=Gorlatov S, Medved L |title=Interaction of fibrin(ogen) with the endothelial cell receptor VE-cadherin: mapping of the receptor-binding site in the NH2-terminal portions of the fibrin beta chains. |journal=Biochemistry |volume=41 |issue= 12 |pages= 4107–16 |year= 2002 |pmid= 11900554 |doi=
*cite journal | author=Di Simone N, Castellani R, Caliandro D, Caruso A |title=Antiphospholid antibodies regulate the expression of trophoblast cell adhesion molecules. |journal=Fertil. Steril. |volume=77 |issue= 4 |pages= 805–11 |year= 2003 |pmid= 11937138 |doi=
*cite journal | author=Zanetti A, Lampugnani MG, Balconi G, "et al." |title=Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=22 |issue= 4 |pages= 617–22 |year= 2002 |pmid= 11950700 |doi=
*cite journal | author=Lampugnani MG, Zanetti A, Breviario F, "et al." |title=VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. |journal=Mol. Biol. Cell |volume=13 |issue= 4 |pages= 1175–89 |year= 2002 |pmid= 11950930 |doi= 10.1091/mbc.01-07-0368
*cite journal | author=Shasby DM, Ries DR, Shasby SS, Winter MC |title=Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=282 |issue= 6 |pages= L1330–8 |year= 2002 |pmid= 12003790 |doi= 10.1152/ajplung.00329.2001

External links


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