BIRC2

Baculoviral IAP repeat-containing 2, also known as BIRC2, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals.cite web | title = Entrez Gene: BIRC2 baculoviral IAP repeat-containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=329| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Rothe M, Pan MG, Henzel WJ, "et al." |title=The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. |journal=Cell |volume=83 |issue= 7 |pages= 1243–52 |year= 1996 |pmid= 8548810 |doi=
*cite journal | author=Liston P, Roy N, Tamai K, "et al." |title=Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. |journal=Nature |volume=379 |issue= 6563 |pages= 349–53 |year= 1996 |pmid= 8552191 |doi= 10.1038/379349a0
*cite journal | author=Uren AG, Pakusch M, Hawkins CJ, "et al." |title=Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 4974–8 |year= 1996 |pmid= 8643514 |doi=
*cite journal | author=Rajcan-Separovic E, Liston P, Lefebvre C, Korneluk RG |title=Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization. |journal=Genomics |volume=37 |issue= 3 |pages= 404–6 |year= 1997 |pmid= 8938457 |doi= 10.1006/geno.1996.0579
*cite journal | author=Shu HB, Takeuchi M, Goeddel DV |title=The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 13973–8 |year= 1997 |pmid= 8943045 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Roy N, Deveraux QL, Takahashi R, "et al." |title=The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. |journal=EMBO J. |volume=16 |issue= 23 |pages= 6914–25 |year= 1998 |pmid= 9384571 |doi= 10.1093/emboj/16.23.6914
*cite journal | author=Deveraux QL, Roy N, Stennicke HR, "et al." |title=IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. |journal=EMBO J. |volume=17 |issue= 8 |pages= 2215–23 |year= 1998 |pmid= 9545235 |doi= 10.1093/emboj/17.8.2215
*cite journal | author=McCarthy JV, Ni J, Dixit VM |title=RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16968–75 |year= 1998 |pmid= 9642260 |doi=
*cite journal | author=Young SS, Liston P, Xuan JY, "et al." |title=Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2. |journal=Mamm. Genome |volume=10 |issue= 1 |pages= 44–8 |year= 1999 |pmid= 9892732 |doi=
*cite journal | author=Hinds MG, Norton RS, Vaux DL, Day CL |title=Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat. |journal=Nat. Struct. Biol. |volume=6 |issue= 7 |pages= 648–51 |year= 1999 |pmid= 10404221 |doi= 10.1038/10701
*cite journal | author=Verhagen AM, Ekert PG, Pakusch M, "et al." |title=Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. |journal=Cell |volume=102 |issue= 1 |pages= 43–53 |year= 2000 |pmid= 10929712 |doi=
*cite journal | author=Vucic D, Stennicke HR, Pisabarro MT, "et al." |title=ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. |journal=Curr. Biol. |volume=10 |issue= 21 |pages= 1359–66 |year= 2001 |pmid= 11084335 |doi=
*cite journal | author=Werneburg BG, Zoog SJ, Dang TT, "et al." |title=Molecular characterization of CD40 signaling intermediates. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43334–42 |year= 2001 |pmid= 11562359 |doi= 10.1074/jbc.M104994200
*cite journal | author=Suzuki Y, Imai Y, Nakayama H, "et al." |title=A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. |journal=Mol. Cell |volume=8 |issue= 3 |pages= 613–21 |year= 2001 |pmid= 11583623 |doi=
*cite journal | author=Verhagen AM, Silke J, Ekert PG, "et al." |title=HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 445–54 |year= 2002 |pmid= 11604410 |doi= 10.1074/jbc.M109891200
*cite journal | author=Mellström B, Ceña V, Lamas M, "et al." |title=Gas1 is induced during and participates in excitotoxic neuronal death. |journal=Mol. Cell. Neurosci. |volume=19 |issue= 3 |pages= 417–29 |year= 2002 |pmid= 11906213 |doi= 10.1006/mcne.2001.1092
*cite journal | author=Li X, Yang Y, Ashwell JD |title=TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. |journal=Nature |volume=416 |issue= 6878 |pages= 345–7 |year= 2002 |pmid= 11907583 |doi= 10.1038/416345a
*cite journal | author=Imoto I, Tsuda H, Hirasawa A, "et al." |title=Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. |journal=Cancer Res. |volume=62 |issue= 17 |pages= 4860–6 |year= 2002 |pmid= 12208731 |doi=

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