Sodium-hydrogen antiporter 1

Sodium-hydrogen antiporter 1

The Sodium-hydrogen antiporter 1 is an isoform of sodium-hydrogen antiporters.


It is a solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive)"',


It is encoded by the gene "SLC9A1".

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Further reading

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*cite journal | author=Cingolani HE, Ennis IL |title=Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy. |journal=Circulation |volume=115 |issue= 9 |pages= 1090–100 |year= 2007 |pmid= 17339567 |doi= 10.1161/CIRCULATIONAHA.106.626929
*cite journal | author=Meima ME, Mackley JR, Barber DL |title=Beyond ion translocation: structural functions of the sodium-hydrogen exchanger isoform-1. |journal=Curr. Opin. Nephrol. Hypertens. |volume=16 |issue= 4 |pages= 365–72 |year= 2007 |pmid= 17565280 |doi= 10.1097/MNH.0b013e3281bd888d
*cite journal | author=Tse CM, Ma AI, Yang VW, "et al." |title=Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger. |journal=EMBO J. |volume=10 |issue= 8 |pages= 1957–67 |year= 1991 |pmid= 1712287 |doi=
*cite journal | author=Dudley CR, Giuffra LA, Tippett P, "et al." |title=The Na+/H+ antiporter: a "melt" polymorphism allows regional mapping to the short arm of chromosome 1. |journal=Hum. Genet. |volume=86 |issue= 1 |pages= 79–83 |year= 1991 |pmid= 1979310 |doi=
*cite journal | author=Sardet C, Counillon L, Franchi A, Pouysségur J |title=Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD. |journal=Science |volume=247 |issue= 4943 |pages= 723–6 |year= 1990 |pmid= 2154036 |doi=
*cite journal | author=Sardet C, Franchi A, Pouysségur J |title=Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter. |journal=Cell |volume=56 |issue= 2 |pages= 271–80 |year= 1989 |pmid= 2536298 |doi=
*cite journal | author=Mattei MG, Sardet C, Franchi A, Pouysségur J |title=The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=48 |issue= 1 |pages= 6–8 |year= 1988 |pmid= 2846238 |doi=
*cite journal | author=Counillon L, Pouysségur J, Reithmeier RA |title=The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain. |journal=Biochemistry |volume=33 |issue= 34 |pages= 10463–9 |year= 1994 |pmid= 8068684 |doi=
*cite journal | author=Fliegel L, Dyck JR, Wang H, "et al." |title=Cloning and analysis of the human myocardial Na+/H+ exchanger. |journal=Mol. Cell. Biochem. |volume=125 |issue= 2 |pages= 137–43 |year= 1994 |pmid= 8283968 |doi=
*cite journal | author=Lin X, Barber DL |title=A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 22 |pages= 12631–6 |year= 1996 |pmid= 8901634 |doi=
*cite journal | author=Shrode LD, Gan BS, D'Souza SJ, "et al." |title=Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage. |journal=Am. J. Physiol. |volume=275 |issue= 2 Pt 1 |pages= C431–9 |year= 1998 |pmid= 9688597 |doi=
*cite journal | author=Wakabayashi S, Pang T, Su X, Shigekawa M |title=A novel topology model of the human Na(+)/H(+) exchanger isoform 1. |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7942–9 |year= 2000 |pmid= 10713111 |doi=
*cite journal | author=Garden OA, Musk P, Worthington-White DA, "et al." |title=Silent polymorphisms within the coding region of human sodium/hydrogen exchanger isoform-1 cDNA in peripheral blood mononuclear cells of leukemia patients: A comparison with healthy controls. |journal=Cancer Genet. Cytogenet. |volume=120 |issue= 1 |pages= 37–43 |year= 2000 |pmid= 10913675 |doi=
*cite journal | author=Denker SP, Huang DC, Orlowski J, "et al." |title=Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation. |journal=Mol. Cell |volume=6 |issue= 6 |pages= 1425–36 |year= 2001 |pmid= 11163215 |doi=
*cite journal | author=Lehoux S, Abe Ji , Florian JA, Berk BC |title=14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange. |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 15794–800 |year= 2001 |pmid= 11279064 |doi= 10.1074/jbc.M100410200
*cite journal | author=Pang T, Su X, Wakabayashi S, Shigekawa M |title=Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17367–72 |year= 2001 |pmid= 11350981 |doi= 10.1074/jbc.M100296200
*cite journal | author=Yan W, Nehrke K, Choi J, Barber DL |title=The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31349–56 |year= 2001 |pmid= 11369779 |doi= 10.1074/jbc.M102679200
*cite journal | author=Khaled AR, Moor AN, Li A, "et al." |title=Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization. |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7545–57 |year= 2001 |pmid= 11604491 |doi= 10.1128/MCB.21.22.7545-7557.2001
*cite journal | author=Mailänder J, Müller-Esterl W, Dedio J |title=Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1. |journal=FEBS Lett. |volume=507 |issue= 3 |pages= 331–5 |year= 2001 |pmid= 11696366 |doi=
*cite journal | author=Shen MR, Wilkins RJ, Chou CY, Ellory JC |title=Anion exchanger isoform 2 operates in parallel with Na(+)/H(+) exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells. |journal=FEBS Lett. |volume=512 |issue= 1-3 |pages= 52–8 |year= 2002 |pmid= 11852051 |doi=

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