S100 calcium binding protein A4, also known as S100A4, is a human gene.

section_title =
summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [cite web | title = Entrez Gene: S100A4 S100 calcium binding protein A4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6275| accessdate = ]


Further reading

citations =
*cite journal | author=Kalluri R, Neilson EG |title=Epithelial-mesenchymal transition and its implications for fibrosis. |journal=J. Clin. Invest. |volume=112 |issue= 12 |pages= 1776–84 |year= 2004 |pmid= 14679171 |doi= 10.1172/JCI200320530
*cite journal | author=Garrett SC, Varney KM, Weber DJ, Bresnick AR |title=S100A4, a mediator of metastasis. |journal=J. Biol. Chem. |volume=281 |issue= 2 |pages= 677–80 |year= 2006 |pmid= 16243835 |doi= 10.1074/jbc.R500017200
*cite journal | author=Tarabykina S, Griffiths TR, Tulchinsky E, "et al." |title=Metastasis-associated protein S100A4: spotlight on its role in cell migration. |journal=Current cancer drug targets |volume=7 |issue= 3 |pages= 217–28 |year= 2007 |pmid= 17504119 |doi=
*cite journal | author=Tulchinsky E, Ford HL, Kramerov D, "et al." |title=Transcriptional analysis of the mts1 gene with specific reference to 5' flanking sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 19 |pages= 9146–50 |year= 1992 |pmid= 1329089 |doi=
*cite journal | author=Engelkamp D, Schäfer BW, Erne P, Heizmann CW |title=S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart. |journal=Biochemistry |volume=31 |issue= 42 |pages= 10258–64 |year= 1992 |pmid= 1384693 |doi=
*cite journal | author=Tomida Y, Terasawa M, Kobayashi R, Hidaka H |title=Calcyclin and calvasculin exist in human platelets. |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 3 |pages= 1310–6 |year= 1993 |pmid= 1482346 |doi=
*cite journal | author=Stoler A, Bouck N |title=Identification of a single chromosome in the normal human genome essential for suppression of hamster cell transformation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 2 |pages= 570–4 |year= 1985 |pmid= 3155863 |doi=
*cite journal | author=Ambartsumian N, Tarabykina S, Grigorian M, "et al." |title=Characterization of two splice variants of metastasis-associated human mts1 gene. |journal=Gene |volume=159 |issue= 1 |pages= 125–30 |year= 1995 |pmid= 7607566 |doi=
*cite journal | author=Schäfer BW, Wicki R, Engelkamp D, "et al." |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638–43 |year= 1995 |pmid= 7759097 |doi=
*cite journal | author=Takenaga K, Nakamura Y, Sakiyama S, "et al." |title=Binding of pEL98 protein, an S100-related calcium-binding protein, to nonmuscle tropomyosin. |journal=J. Cell Biol. |volume=124 |issue= 5 |pages= 757–68 |year= 1994 |pmid= 8120097 |doi=
*cite journal | author=Pedrocchi M, Schäfer BW, Durussel I, "et al." |title=Purification and characterization of the recombinant human calcium-binding S100 proteins CAPL and CACY. |journal=Biochemistry |volume=33 |issue= 21 |pages= 6732–8 |year= 1994 |pmid= 8204608 |doi=
*cite journal | author=Engelkamp D, Schäfer BW, Mattei MG, "et al." |title=Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6547–51 |year= 1993 |pmid= 8341667 |doi=
*cite journal | author=Ford HL, Silver DL, Kachar B, "et al." |title=Effect of Mts1 on the structure and activity of nonmuscle myosin II. |journal=Biochemistry |volume=36 |issue= 51 |pages= 16321–7 |year= 1998 |pmid= 9405067 |doi= 10.1021/bi971182l
*cite journal | author=Liu JH, Wei S, Burnette PK, "et al." |title=Functional association of TGF-beta receptor II with cyclin B. |journal=Oncogene |volume=18 |issue= 1 |pages= 269–75 |year= 1999 |pmid= 9926943 |doi= 10.1038/sj.onc.1202263
*cite journal | author=Wang G, Rudland PS, White MR, Barraclough R |title=Interaction in vivo and in vitro of the metastasis-inducing S100 protein, S100A4 (p9Ka) with S100A1. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 11141–6 |year= 2000 |pmid= 10753920 |doi=
*cite journal | author=Tarabykina S, Kriajevska M, Scott DJ, "et al." |title=Heterocomplex formation between metastasis-related protein S100A4 (Mts1) and S100A1 as revealed by the yeast two-hybrid system. |journal=FEBS Lett. |volume=475 |issue= 3 |pages= 187–91 |year= 2000 |pmid= 10869553 |doi=
*cite journal | author=Tarabykina S, Scott DJ, Herzyk P, "et al." |title=The dimerization interface of the metastasis-associated protein S100A4 (Mts1): in vivo and in vitro studies. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24212–22 |year= 2001 |pmid= 11278510 |doi= 10.1074/jbc.M009477200
*cite journal | author=Grigorian M, Andresen S, Tulchinsky E, "et al." |title=Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1/S100A4 protein: functional consequences of their interaction. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22699–708 |year= 2001 |pmid= 11278647 |doi= 10.1074/jbc.M010231200
*cite journal | author=Chen H, Fernig DG, Rudland PS, "et al." |title=Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka). |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 5 |pages= 1212–7 |year= 2001 |pmid= 11527429 |doi= 10.1006/bbrc.2001.5517
*cite journal | author=Zhang H, Wang Z, Ding Y, "et al." |title=Crystallization and preliminary crystallographic analysis of a metastasis-inducing protein, human S100A4. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=58 |issue= Pt 1 |pages= 127–9 |year= 2002 |pmid= 11752788 |doi=

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