FOXO1A

Forkhead box O1A (rhabdomyosarcoma), also known as FOXO1A, is a human gene.

PBB_Summary
section_title =
summary_text = This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [cite web | title = Entrez Gene: FOXO1A forkhead box O1A (rhabdomyosarcoma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2308| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sublett JE, Jeon IS, Shapiro DN |title=The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator. |journal=Oncogene |volume=11 |issue= 3 |pages= 545–52 |year= 1995 |pmid= 7630639 |doi=
*cite journal | author=Fredericks WJ, Galili N, Mukhopadhyay S, "et al." |title=The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. |journal=Mol. Cell. Biol. |volume=15 |issue= 3 |pages= 1522–35 |year= 1995 |pmid= 7862145 |doi=
*cite journal | author=Galili N, Davis RJ, Fredericks WJ, "et al." |title=Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. |journal=Nat. Genet. |volume=5 |issue= 3 |pages= 230–5 |year= 1994 |pmid= 8275086 |doi= 10.1038/ng1193-230
*cite journal | author=Scheidler S, Fredericks WJ, Rauscher FJ, "et al." |title=The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 18 |pages= 9805–9 |year= 1996 |pmid= 8790412 |doi=
*cite journal | author=Anderson MJ, Viars CS, Czekay S, "et al." |title=Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. |journal=Genomics |volume=47 |issue= 2 |pages= 187–99 |year= 1998 |pmid= 9479491 |doi= 10.1006/geno.1997.5122
*cite journal | author=Tang ED, Nuñez G, Barr FG, Guan KL |title=Negative regulation of the forkhead transcription factor FKHR by Akt. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16741–6 |year= 1999 |pmid= 10358014 |doi=
*cite journal | author=Rena G, Guo S, Cichy SC, "et al." |title=Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 17179–83 |year= 1999 |pmid= 10358075 |doi=
*cite journal | author=Medema RH, Kops GJ, Bos JL, Burgering BM |title=AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. |journal=Nature |volume=404 |issue= 6779 |pages= 782–7 |year= 2000 |pmid= 10783894 |doi= 10.1038/35008115
*cite journal | author=Margue CM, Bernasconi M, Barr FG, Schäfer BW |title=Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR. |journal=Oncogene |volume=19 |issue= 25 |pages= 2921–9 |year= 2000 |pmid= 10871843 |doi= 10.1038/sj.onc.1203607
*cite journal | author=Nasrin N, Ogg S, Cahill CM, "et al." |title=DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 19 |pages= 10412–7 |year= 2000 |pmid= 10973497 |doi= 10.1073/pnas.190326997
*cite journal | author=Jackson JG, Kreisberg JI, Koterba AP, "et al." |title=Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells. |journal=Oncogene |volume=19 |issue= 40 |pages= 4574–81 |year= 2000 |pmid= 11030146 |doi= 10.1038/sj.onc.1203825
*cite journal | author=Rena G, Prescott AR, Guo S, "et al." |title=Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting. |journal=Biochem. J. |volume=354 |issue= Pt 3 |pages= 605–12 |year= 2001 |pmid= 11237865 |doi=
*cite journal | author=Woods YL, Rena G, Morrice N, "et al." |title=The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. |journal=Biochem. J. |volume=355 |issue= Pt 3 |pages= 597–607 |year= 2001 |pmid= 11311120 |doi=
*cite journal | author=Zhao HH, Herrera RE, Coronado-Heinsohn E, "et al." |title=Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 27907–12 |year= 2001 |pmid= 11353774 |doi= 10.1074/jbc.M104278200
*cite journal | author=Schuur ER, Loktev AV, Sharma M, "et al." |title=Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33554–60 |year= 2001 |pmid= 11435445 |doi= 10.1074/jbc.M105555200
*cite journal | author=Patel S, Lochhead PA, Rena G, Sutherland C |title=Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression. |journal=Biochem. J. |volume=359 |issue= Pt 3 |pages= 611–9 |year= 2001 |pmid= 11672436 |doi=
*cite journal | author=Ayalon D, Glaser T, Werner H |title=Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein. |journal=Growth Horm. IGF Res. |volume=11 |issue= 5 |pages= 289–97 |year= 2002 |pmid= 11735247 |doi= 10.1054/ghir.2001.0244
*cite journal | author=Christian M, Zhang X, Schneider-Merck T, "et al." |title=Cyclic AMP-induced forkhead transcription factor, FKHR, cooperates with CCAAT/enhancer-binding protein beta in differentiating human endometrial stromal cells. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20825–32 |year= 2002 |pmid= 11893744 |doi= 10.1074/jbc.M201018200
*cite journal | author=Rena G, Woods YL, Prescott AR, "et al." |title=Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. |journal=EMBO J. |volume=21 |issue= 9 |pages= 2263–71 |year= 2002 |pmid= 11980723 |doi= 10.1093/emboj/21.9.2263
*cite journal | author=Sorensen PH, Lynch JC, Qualman SJ, "et al." |title=PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group. |journal=J. Clin. Oncol. |volume=20 |issue= 11 |pages= 2672–9 |year= 2002 |pmid= 12039929 |doi=

External links

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