Peptidylprolyl isomerase A

Peptidylprolyl isomerase A
Peptidylprolyl isomerase A (cyclophilin A)

PDB rendering based on 1ak4.
Symbols PPIA; CYPA; CYPH; MGC117158; MGC12404; MGC23397
External IDs OMIM123840 MGI3648545 HomoloGene115610 GeneCards: PPIA Gene
EC number
Species Human Mouse
Entrez 5478 268373
Ensembl ENSG00000196262 n/a
UniProt P62937 n/a
RefSeq (mRNA) NM_021130.3 XM_001002180
RefSeq (protein) NP_066953.1 NP_032933.1
Location (UCSC) Chr 7:
44.84 – 44.86 Mb
PubMed search [1] [2]

Peptidylprolyl isomerase A also known as cyclophilin A or rotamase A is an enzyme that in humans is encoded by the PPIA gene.[1][2][3]



This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.[1]


Peptidylprolyl isomerase A has been shown to interact with ITK.[4]

See also


  1. ^ a b "Entrez Gene: PPIA peptidylprolyl isomerase A (cyclophilin A)". 
  2. ^ Haendler B, Hofer E (July 1990). "Characterization of the human cyclophilin gene and of related processed pseudogenes". Eur. J. Biochem. 190 (3): 477–82. doi:10.1111/j.1432-1033.1990.tb15598.x. PMID 2197089. 
  3. ^ Holzman TF, Egan DA, Edalji R, Simmer RL, Helfrich R, Taylor A, Burres NS (February 1991). "Preliminary characterization of a cloned neutral isoelectric form of the human peptidyl prolyl isomerase cyclophilin". J. Biol. Chem. 266 (4): 2474–9. PMID 1989998. 
  4. ^ Brazin, Kristine N; Mallis Robert J, Fulton D Bruce, Andreotti Amy H (Feb. 2002). "Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (4): 1899–904. doi:10.1073/pnas.042529199. ISSN 0027-8424. PMC 122291. PMID 11830645. 

Further reading

  • Franke EK, Luban J (1995). "Cyclophilin and gag in HIV-1 replication and pathogenesis". Adv. Exp. Med. Biol.. Advances in Experimental Medicine and Biology 374: 217–28. doi:10.1007/978-1-4615-1995-9_19. ISBN 978-0-306-45063-1. PMID 7572395. 
  • Sokolskaja E, Luban J (2006). "Cyclophilin, TRIM5, and innate immunity to HIV-1". Curr. Opin. Microbiol. 9 (4): 404–8. doi:10.1016/j.mib.2006.06.011. PMID 16815734.