ATP-dependent DNA helicase 2 subunit 2

ATP-dependent DNA helicase 2 subunit 2

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa), also known as XRCC5, is a human gene.

section_title =
summary_text = The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependent DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.cite web | title = Entrez Gene: XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa)| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Koike M |title=Dimerization, translocation and localization of Ku70 and Ku80 proteins. |journal=J. Radiat. Res. |volume=43 |issue= 3 |pages= 223–36 |year= 2003 |pmid= 12518983 |doi=
*cite journal | author=Chen DJ, Park MS, Campbell E, "et al." |title=Assignment of a human DNA double-strand break repair gene (XRCC5) to chromosome 2. |journal=Genomics |volume=13 |issue= 4 |pages= 1088–94 |year= 1992 |pmid= 1505945 |doi=
*cite journal | author=Wedrychowski A, Henzel W, Huston L, "et al." |title=Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells. |journal=J. Biol. Chem. |volume=267 |issue= 7 |pages= 4533–40 |year= 1992 |pmid= 1537839 |doi=
*cite journal | author=Jeggo PA, Hafezparast M, Thompson AF, "et al." |title=Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 14 |pages= 6423–7 |year= 1992 |pmid= 1631138 |doi=
*cite journal | author=Knuth MW, Gunderson SI, Thompson NE, "et al." |title=Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter. |journal=J. Biol. Chem. |volume=265 |issue= 29 |pages= 17911–20 |year= 1990 |pmid= 2211668 |doi=
*cite journal | author=Stuiver MH, Coenjaerts FE, van der Vliet PC |title=The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes. |journal=J. Exp. Med. |volume=172 |issue= 4 |pages= 1049–54 |year= 1990 |pmid= 2212941 |doi=
*cite journal | author=Mimori T, Ohosone Y, Hama N, "et al." |title=Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 5 |pages= 1777–81 |year= 1990 |pmid= 2308937 |doi=
*cite journal | author=Yaneva M, Wen J, Ayala A, Cook R |title=cDNA-derived amino acid sequence of the 86-kDa subunit of the Ku antigen. |journal=J. Biol. Chem. |volume=264 |issue= 23 |pages= 13407–11 |year= 1989 |pmid= 2760028 |doi=
*cite journal | author=Genersch E, Eckerskorn C, Lottspeich F, "et al." |title=Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen. |journal=EMBO J. |volume=14 |issue= 4 |pages= 791–800 |year= 1995 |pmid= 7882982 |doi=
*cite journal | author=Tuteja N, Tuteja R, Ochem A, "et al." |title=Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. |journal=EMBO J. |volume=13 |issue= 20 |pages= 4991–5001 |year= 1994 |pmid= 7957065 |doi=
*cite journal | author=Le Romancer M, Reyl-Desmars F, Cherifi Y, "et al." |title=The 86-kDa subunit of autoantigen Ku is a somatostatin receptor regulating protein phosphatase-2A activity. |journal=J. Biol. Chem. |volume=269 |issue= 26 |pages= 17464–8 |year= 1994 |pmid= 8021251 |doi=
*cite journal | author=Cao QP, Pitt S, Leszyk J, Baril EF |title=DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen. |journal=Biochemistry |volume=33 |issue= 28 |pages= 8548–57 |year= 1994 |pmid= 8031790 |doi=
*cite journal | author=Taccioli GE, Gottlieb TM, Blunt T, "et al." |title=Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. |journal=Science |volume=265 |issue= 5177 |pages= 1442–5 |year= 1994 |pmid= 8073286 |doi=
*cite journal | author=Chen DJ, Marrone BL, Nguyen T, "et al." |title=Regional assignment of a human DNA repair gene (XRCC5) to 2q35 by X-ray hybrid mapping. |journal=Genomics |volume=21 |issue= 2 |pages= 423–7 |year= 1994 |pmid= 8088837 |doi= 10.1006/geno.1994.1287
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Kaczmarski W, Khan SA |title=Lupus autoantigen Ku protein binds HIV-1 TAR RNA in vitro. |journal=Biochem. Biophys. Res. Commun. |volume=196 |issue= 2 |pages= 935–42 |year= 1993 |pmid= 8240370 |doi= 10.1006/bbrc.1993.2339
*cite journal | author=Blunt T, Taccioli GE, Priestley A, "et al." |title=A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion. |journal=Genomics |volume=30 |issue= 2 |pages= 320–8 |year= 1996 |pmid= 8586433 |doi=
*cite journal | author=Warriar N, Pagé N, Govindan MV |title=Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18662–71 |year= 1996 |pmid= 8702520 |doi=
*cite journal | author=Myung K, He DM, Lee SE, Hendrickson EA |title=KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity. |journal=EMBO J. |volume=16 |issue= 11 |pages= 3172–84 |year= 1997 |pmid= 9214634 |doi= 10.1093/emboj/16.11.3172
*cite journal | author=Jin S, Kharbanda S, Mayer B, "et al." |title=Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 24763–6 |year= 1997 |pmid= 9312071 |doi=

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