Histone deacetylase 2


Histone deacetylase 2

Histone deacetylase 2, also known as HDAC2, is a human gene.

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summary_text = This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.cite web | title = Entrez Gene: HDAC2 histone deacetylase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3066| accessdate = ]

ee also

* Histone deacetylase

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ahringer J |title=NuRD and SIN3 histone deacetylase complexes in development. |journal=Trends Genet. |volume=16 |issue= 8 |pages= 351–6 |year= 2000 |pmid= 10904264 |doi=
*cite journal | author=Verdin E, Dequiedt F, Kasler HG |title=Class II histone deacetylases: versatile regulators. |journal=Trends Genet. |volume=19 |issue= 5 |pages= 286–93 |year= 2003 |pmid= 12711221 |doi=
*cite journal | author=Zhang Y, Dufau ML |title=Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 401–14 |year= 2003 |pmid= 12943729 |doi=
*cite journal | author=Furukawa Y, Kawakami T, Sudo K, "et al." |title=Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 130–3 |year= 1996 |pmid= 8646880 |doi=
*cite journal | author=Yang WM, Inouye C, Zeng Y, "et al." |title=Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 23 |pages= 12845–50 |year= 1996 |pmid= 8917507 |doi=
*cite journal | author=Laherty CD, Yang WM, Sun JM, "et al." |title=Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. |journal=Cell |volume=89 |issue= 3 |pages= 349–56 |year= 1997 |pmid= 9150134 |doi=
*cite journal | author=Zhang Y, Iratni R, Erdjument-Bromage H, "et al." |title=Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. |journal=Cell |volume=89 |issue= 3 |pages= 357–64 |year= 1997 |pmid= 9150135 |doi=
*cite journal | author=Yang WM, Yao YL, Sun JM, "et al." |title=Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 28001–7 |year= 1997 |pmid= 9346952 |doi=
*cite journal | author=Hassig CA, Tong JK, Fleischer TC, "et al." |title=A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 7 |pages= 3519–24 |year= 1998 |pmid= 9520398 |doi=
*cite journal | author=Randhawa GS, Bell DW, Testa JR, Feinberg AP |title=Identification and mapping of human histone acetylation modifier gene homologues. |journal=Genomics |volume=51 |issue= 2 |pages= 262–9 |year= 1998 |pmid= 9722949 |doi= 10.1006/geno.1998.5370
*cite journal | author=Betz R, Gray SG, Ekström C, "et al." |title=Human histone deacetylase 2, HDAC2 (Human RPD3), is localized to 6q21 by radiation hybrid mapping. |journal=Genomics |volume=52 |issue= 2 |pages= 245–6 |year= 1998 |pmid= 9782097 |doi= 10.1006/geno.1998.5435
*cite journal | author=Zhang Y, LeRoy G, Seelig HP, "et al." |title=The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. |journal=Cell |volume=95 |issue= 2 |pages= 279–89 |year= 1998 |pmid= 9790534 |doi=
*cite journal | author=Tong JK, Hassig CA, Schnitzler GR, "et al." |title=Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. |journal=Nature |volume=395 |issue= 6705 |pages= 917–21 |year= 1998 |pmid= 9804427 |doi= 10.1038/27699
*cite journal | author=Hsieh JJ, Zhou S, Chen L, "et al." |title=CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 1 |pages= 23–8 |year= 1999 |pmid= 9874765 |doi=
*cite journal | author=Yarden RI, Brody LC |title=BRCA1 interacts with components of the histone deacetylase complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 4983–8 |year= 1999 |pmid= 10220405 |doi=
*cite journal | author=Koipally J, Renold A, Kim J, Georgopoulos K |title=Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. |journal=EMBO J. |volume=18 |issue= 11 |pages= 3090–100 |year= 1999 |pmid= 10357820 |doi= 10.1093/emboj/18.11.3090
*cite journal | author=Zhang Y, Ng HH, Erdjument-Bromage H, "et al." |title=Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. |journal=Genes Dev. |volume=13 |issue= 15 |pages= 1924–35 |year= 1999 |pmid= 10444591 |doi=
*cite journal | author=Ng HH, Zhang Y, Hendrich B, "et al." |title=MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. |journal=Nat. Genet. |volume=23 |issue= 1 |pages= 58–61 |year= 1999 |pmid= 10471499 |doi= 10.1038/12659
*cite journal | author=Wade PA, Gegonne A, Jones PL, "et al." |title=Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. |journal=Nat. Genet. |volume=23 |issue= 1 |pages= 62–6 |year= 1999 |pmid= 10471500 |doi= 10.1038/12664
*cite journal | author=Lai A, Lee JM, Yang WM, "et al." |title=RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6632–41 |year= 2000 |pmid= 10490602 |doi=

External links

*

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Look at other dictionaries:

  • Histone deacetylase — Histone deacetylases (HDAC) (EC number 3.5.1) are a class of enzymes that remove acetyl groups from an ε N acetyl lysine amino acid on a histone. Its action is opposite to that of histone acetyltransferase.ubtypesHDAC proteins are found in three… …   Wikipedia

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  • histone deacetylase — noun Any of a class of enzymes that remove acetyl groups from lysine amino acids in proteins, especially the histone proteins of the nucleus …   Wiktionary

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