Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha, also known as PPARGC1A or PGC-1α, is a human gene.PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPAR-γ, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [cite web | title = Entrez Gene: PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10891| accessdate = ]

ee also

* Transcription coregulator


External links


Further reading

citations =
*cite journal | author=Knutti D, Kralli A |title=PGC-1, a versatile coactivator. |journal=Trends Endocrinol. Metab. |volume=12 |issue= 8 |pages= 360–5 |year= 2001 |pmid= 11551810 |doi=10.1016/S1043-2760(01)00457-X
*cite journal | author=Puigserver P, Spiegelman BM |title=Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. |journal=Endocr. Rev. |volume=24 |issue= 1 |pages= 78–90 |year= 2003 |pmid= 12588810 |doi=10.1210/er.2002-0012
*cite journal | author=Soyal S, Krempler F, Oberkofler H, Patsch W |title=PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes. |journal=Diabetologia |volume=49 |issue= 7 |pages= 1477–88 |year= 2007 |pmid= 16752166 |doi= 10.1007/s00125-006-0268-6
*cite journal | author=Handschin C, Spiegelman BM |title=Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. |journal=Endocr. Rev. |volume=27 |issue= 7 |pages= 728–35 |year= 2007 |pmid= 17018837 |doi= 10.1210/er.2006-0037
*cite journal | author=Liang H, Ward WF |title=PGC-1alpha: a key regulator of energy metabolism. |journal=Advances in physiology education |volume=30 |issue= 4 |pages= 145–51 |year= 2006 |pmid= 17108241 |doi= 10.1152/advan.00052.2006

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