Cholesterol 24-hydroxylase


Cholesterol 24-hydroxylase
Cholesterol 24-hydroxylase
Identifiers
EC number 1.14.13.98
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a cholesterol 24-hydroxylase (EC 1.14.13.98) is an enzyme that catalyzes the chemical reaction

cholesterol + NADPH + H+ + O2 \rightleftharpoons (24S)-24-hydroxycholesterol + NADP+ + H2O

The 4 substrates of this enzyme are cholesterol, NADPH, H+, and O2, whereas its 3 products are (24S)-24-hydroxycholesterol, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating). Other names in common use include cholesterol 24-monooxygenase, CYP46, CYP46A1, cholesterol 24S-hydroxylase, and cytochrome P450 46A1.

References