Caveolin 1


Caveolin 1

:"For other meanings, see CAV-1."Caveolin 1, caveolae protein, 22kDa, also known as CAV1, is a human gene.

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summary_text = The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. [cite web | title = Entrez Gene: CAV1 caveolin 1, caveolae protein, 22kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=857| accessdate = ]

ee also

* Caveolin

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Engelman JA, Zhang X, Galbiati F, "et al." |title=Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy. |journal=Am. J. Hum. Genet. |volume=63 |issue= 6 |pages= 1578–87 |year= 1999 |pmid= 9837809 |doi=
*cite journal | author=Razani B, Schlegel A, Liu J, Lisanti MP |title=Caveolin-1, a putative tumour suppressor gene. |journal=Biochem. Soc. Trans. |volume=29 |issue= Pt 4 |pages= 494–9 |year= 2002 |pmid= 11498016 |doi=
*cite journal | author=Fujimoto T, Kogo H, Nakamura N, Ozeki S |title= [Microdomains and caveolin] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 4 Suppl |pages= 326–32 |year= 2002 |pmid= 11915322 |doi=
*cite journal | author=Shatz M, Liscovitch M |title=Caveolin-1 and cancer multidrug resistance: coordinate regulation of pro-survival proteins? |journal=Leuk. Res. |volume=28 |issue= 9 |pages= 907–8 |year= 2004 |pmid= 15234566 |doi= 10.1016/j.leukres.2004.03.013
*cite journal | author=Frank PG, Lisanti MP |title=Caveolin-1 and liver regeneration: role in proliferation and lipogenesis. |journal=Cell Cycle |volume=6 |issue= 2 |pages= 115–6 |year= 2007 |pmid= 17314510 |doi=

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