MRNA (nucleoside-2'-O-)-methyltransferase

MRNA (nucleoside-2'-O-)-methyltransferase

In enzymology, a mRNA (nucleoside-2'-O-)-methyltransferase (EC number| is an enzyme that catalyzes the chemical reaction

:S-adenosyl-L-methionine + m7G(5')pppR-RNA ightleftharpoons S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA (mRNA containing a 2'-O-methylpurine cap)

Thus, the two substrates of this enzyme are S-adenosyl methionine and m7G(5')pppR-RNA, whereas its two products are S-adenosylhomocysteine and m7G(5')pppRm-RNA (mRNA containing a 2'-O-methylpurine cap).

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase. Other names in common use include messenger ribonucleate nucleoside 2'-methyltransferase, and messenger RNA (nucleoside-2'-)-methyltransferase.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|2GA9 and PDB link|2GAF.



External links

::"The CAS registry number for this enzyme class is CAS registry|61970-02-3."

Gene Ontology (GO) codes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Nucleoside phosphorylase — Nucleoside phosphorylase, also known as NP, is a human gene.cite web | title = Entrez Gene: NP nucleoside phosphorylase| url = Cmd=ShowDetailView TermToSearch=4860| accessdate = ] PBB Summary… …   Wikipedia

  • Nucleoside-diphosphate kinase — Nucleoside diphosphate kinases (NDKs, also NDP Kinase, (poly)nucleotide kinases and nucleoside diphosphokinases) are enzymes that catalyze the exchange of phosphate groups between different nucleoside diphosphates. NDK activities maintain an… …   Wikipedia

  • Nucleoside phosphotransferase — Identifiers EC number CAS number 9055 37 2 …   Wikipedia

  • Purine nucleoside phosphorylase — Not to be confused with polynucleotide phosphorylase. purine nucleoside phosphorylase Identifiers EC number CAS number …   Wikipedia

  • Concentrative nucleoside transporter 1 — Solute carrier family 28 (sodium coupled nucleoside transporter), member 1 Identifiers Symbols SLC28A1; CNT1; HCNT1 External IDs …   Wikipedia

  • Concentrative nucleoside transporter 2 — Solute carrier family 28 (sodium coupled nucleoside transporter), member 2 Identifiers Symbols SLC28A2; CNT2; FLJ21468; HCNT2; HsT17153; MGC138252; SPNT1 External IDs …   Wikipedia

  • metabolism — /meuh tab euh liz euhm/, n. 1. Biol., Physiol. the sum of the physical and chemical processes in an organism by which its material substance is produced, maintained, and destroyed, and by which energy is made available. Cf. anabolism, catabolism …   Universalium

  • NME1 — Non metastatic cells 1, protein (NM23A) expressed in PDB rendering based on 1be4 …   Wikipedia

  • Virus — This article is about the biological agent. For other uses, see Virus (disambiguation). For a generally accessible and less technical introduction to the topic, see Introduction to viruses. Viruses …   Wikipedia

  • nucleic acid — /nooh klee ik, klay , nyooh /, Biochem. any of a group of long, linear macromolecules, either DNA or various types of RNA, that carry genetic information directing all cellular functions: composed of linked nucleotides. [1890 95; NUCLE(US) + IC;… …   Universalium

  • Nucleic acid analogues — Not to be confused with degenerate bases. For phosphoramidite synthesis of nucleic acids, see Oligonucleotide synthesis. RNA with its nucleobases to the left and DNA to the right. Nucleic acid analogues are compounds structurally similar (analog) …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.