MRNA (guanine-N7-)-methyltransferase


MRNA (guanine-N7-)-methyltransferase

In enzymology, a mRNA (guanine-N7-)-methyltransferase (EC number|2.1.1.56) is an enzyme that catalyzes the chemical reaction

:S-adenosyl-L-methionine + G(5')pppR-RNA ightleftharpoons S-adenosyl-L-homocysteine + m7G(5')pppR-RNA (mRNA containing an N7-methylguanine cap)

Thus, the two substrates of this enzyme are S-adenosyl methionine and G(5')pppR-RNA, whereas its two products are S-adenosylhomocysteine and m7G(5')pppR-RNA.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase. Other names in common use include messenger ribonucleate guanine 7-methyltransferase, guanine-7-methyltransferase, messenger RNA guanine 7-methyltransferase, and S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1Z3C and PDB link|2HV9.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|56941-25-4."

Gene Ontology (GO) codes


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