T-box 19, also known as TBX19, is a human gene.

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summary_text = This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx19/Tpit gene. Studies in mouse show that Tpit protein is present only in the two pituitary pro-opiomelanocortin (POMC)-expressing lineages, the corticotrophs and melanotrophs. Mutations in the human ortholog were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. [cite web | title = Entrez Gene: TBX19 T-box 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9095| accessdate = ]


Further reading

citations =
*cite journal | author=Asteria C |title=T-box and isolated ACTH deficiency. |journal=Eur. J. Endocrinol. |volume=146 |issue= 4 |pages= 463–5 |year= 2002 |pmid= 11916612 |doi=

External links


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  • T-box — Pfam box Symbol = T box Name = T box width = caption = Crystallographic structure of the TBX3 protein dimer (cyan and green) complexed with DNA (brown) based on the PDB|1h6f coordinates. Pfam= PF00907 InterPro= IPR001699 SMART= PROSITE = PS50252… …   Wikipedia

  • T-box — Estructura tridimensional de la proteína dimérica TBX3 (azul y verde) unida al ADN (marrón). Identificadores Símbolo T box …   Wikipedia Español

  • Hypopituitarism — Infobox Disease Name = Hypopituitarism Caption = The pituitary gland on a plate from Gray s Anatomy (1918). The anterior lobe is on the left, and the posterior lobe on the right, both in red. DiseasesDB = 6522 ICD10 = ICD10|E|23|0|e|20,… …   Wikipedia