Mitogen-activated protein kinase kinase kinase kinase 1
Symbols MAP4K1; HPK1
External IDs OMIM601983 MGI1346882 HomoloGene5199 GeneCards: MAP4K1 Gene
EC number
RNA expression pattern
PBB GE MAP4K1 214339 s at tn.png
PBB GE MAP4K1 206296 x at tn.png
PBB GE MAP4K1 214219 x at tn.png
More reference expression data
Species Human Mouse
Entrez 11184 26411
Ensembl ENSG00000104814 ENSMUSG00000037337
UniProt Q92918 Q3UJX3
RefSeq (mRNA) NM_001042600.1 NM_008279.2
RefSeq (protein) NP_001036065.1 NP_032305.2
Location (UCSC) Chr 19:
39.08 – 39.11 Mb
Chr 7:
29.77 – 29.79 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.[1]. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1).


MAP4K1 has been shown to interact with B-cell linker,[2] Grb2,[3][4][5][6] CRKL,[3][5][6] Drebrin-like,[7] CRK,[3][5][6] Linker of activated T cells,[6] NCK1[4][5][6] and GRAP2.[8]


  1. ^ Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH (Dec 1996). "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade". Genes Dev 10 (18): 2251–64. doi:10.1101/gad.10.18.2251. PMID 8824585. 
  2. ^ Tsuji, S; Okamoto M, Yamada K, Okamoto N, Goitsuka R, Arnold R, Kiefer F, Kitamura D (Aug. 2001). "B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1". J. Exp. Med. (United States) 194 (4): 529–39. doi:10.1084/jem.194.4.529. ISSN 0022-1007. PMC 2193495. PMID 11514608. 
  3. ^ a b c Oehrl, W; Kardinal C, Ruf S, Adermann K, Groffen J, Feng G S, Blenis J, Tan T H, Feller S M (Oct. 1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene (ENGLAND) 17 (15): 1893–901. doi:10.1038/sj.onc.1202108. ISSN 0950-9232. PMID 9788432. 
  4. ^ a b Anafi, M; Kiefer F, Gish G D, Mbamalu G, Iscove N N, Pawson T (Oct. 1997). "SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1". J. Biol. Chem. (UNITED STATES) 272 (44): 27804–11. doi:10.1074/jbc.272.44.27804. ISSN 0021-9258. PMID 9346925. 
  5. ^ a b c d Ling, P; Yao Z, Meyer C F, Wang X S, Oehrl W, Feller S M, Tan T H (Feb. 1999). "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase". Mol. Cell. Biol. (UNITED STATES) 19 (2): 1359–68. ISSN 0270-7306. PMC 116064. PMID 9891069. 
  6. ^ a b c d e Ling, P; Meyer C F, Redmond L P, Shui J W, Davis B, Rich R R, Hu M C, Wange R L, Tan T H (Jun. 2001). "Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling". J. Biol. Chem. (United States) 276 (22): 18908–14. doi:10.1074/jbc.M101485200. ISSN 0021-9258. PMID 11279207. 
  7. ^ Ensenat, D; Yao Z, Wang X S, Kori R, Zhou G, Lee S C, Tan T H (Nov. 1999). "A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1". J. Biol. Chem. (UNITED STATES) 274 (48): 33945–50. doi:10.1074/jbc.274.48.33945. ISSN 0021-9258. PMID 10567356. 
  8. ^ Ma, W; Xia C, Ling P, Qiu M, Luo Y, Tan T H, Liu M (Mar. 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene (England) 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. ISSN 0950-9232. PMID 11313918. 

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  • Protein kinase domain — Pfam box Symbol = Pkinase Name = Protein kinase domain width = caption = Pfam= PF00069 InterPro= IPR000719 SMART= TyrKc PROSITE = PDOC00629 SCOP = 1apm TCDB = OPM family= OPM protein= 2bcj PDB=PDB3|1ctpE:44 298 PDB3|2erzE:44 298 PDB3|1fotA:87 341 …   Wikipedia

  • Drebrin-like — PDB rendering based on 1x67 …   Wikipedia

  • MAP kinase kinase kinase kinase — Mitogen activated protein kinase kinase kinase kinase (MAP4K) is a family of proteins involved in cellular signal transduction. This list is incomplete; you can help by expanding it. MAP4K1 (aka HPK1) MAP4K2 (aka GCK) MAP4K3 MAP4K4 MAP4K5… …   Wikipedia

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