3-oxoacyl-(acyl-carrier-protein) reductase


3-oxoacyl-(acyl-carrier-protein) reductase

In enzymology, a 3-oxoacyl- [acyl-carrier-protein] reductase (EC number|1.1.1.100) is an enzyme that catalyzes the chemical reaction

:(3R)-3-hydroxyacyl- [acyl-carrier-protein] + NADP+ ightleftharpoons 3-oxoacyl- [acyl-carrier-protein] + NADPH + H+

Thus, the two substrates of this enzyme are [(3R)-3-hydroxyacyl- [acyl-carrier-protein] and NADP+, whereas its 3 products are [3-oxoacyl- [acyl-carrier-protein] , NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (3R)-3-hydroxyacyl- [acyl-carrier-protein] :NADP+ oxidoreductase. Other names in common use include beta-ketoacyl- [acyl-carrier protein] (ACP) reductase, beta-ketoacyl acyl carrier protein (ACP) reductase, beta-ketoacyl reductase, beta-ketoacyl thioester reductase, beta-ketoacyl-ACP reductase, beta-ketoacyl-acyl carrier protein reductase, 3-ketoacyl acyl carrier protein reductase, NADPH-specific 3-oxoacyl- [acylcarrier protein] reductase, and 3-oxoacyl- [ACP] reductase. This enzyme participates in fatty acid biosynthesis and polyunsaturated fatty acid biosynthesis.

tructural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1I01, PDB link|1O5I, PDB link|1Q7B, PDB link|1Q7C, PDB link|1ULS, PDB link|1UZL, PDB link|1UZM, PDB link|1UZN, PDB link|2A4K, PDB link|2B4Q, PDB link|2C07, PDB link|2FR0, PDB link|2FR1, PDB link|2NM0, PDB link|2NTN, PDB link|2P68, PDB link|2PFF, PDB link|2PH3, PDB link|2PNF, PDB link|2UVD, and PDB link|2Z5L.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37250-34-3."

Gene Ontology (GO) codes


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