Glucuronate reductase

Glucuronate reductase

In enzymology, a glucuronate reductase (EC number|1.1.1.19) is an enzyme that catalyzes the chemical reaction

:L-gulonate + NADP+ ightleftharpoons D-glucuronate + NADPH + H+

Thus, the two substrates of this enzyme are L-gulonate and NADP+, whereas its 3 products are D-glucuronate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-gulonate:NADP+ 6-oxidoreductase. Other names in common use include aldehyde reductase, L-hexonate:NADP dehydrogenase, TPN-L-gulonate dehydrogenase, aldehyde reductase II, NADP-L-gulonate dehydrogenase, D-glucuronate dehydrogenase, D-glucuronate reductase, and L-glucuronate reductase (incorrect). This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.

References

*
* Jakoby, W.B. (Ed.), Enzymatic Basis of Detoxication, vol. 1, Academic Press, New York, 1980, p. 249-260.
*

External links

::"The CAS registry number for this enzyme class is CAS registry|9028-29-9."

Gene Ontology (GO) codes


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • D-xylulose reductase — Identifiers EC number 1.1.1.9 CAS number 9028 16 4 …   Wikipedia

  • Tagaturonate reductase — In enzymology, a tagaturonate reductase (EC number|1.1.1.58) is an enzyme that catalyzes the chemical reaction:D altronate + NAD+ ightleftharpoons D tagaturonate + NADH + H+Thus, the two substrates of this enzyme are D altronate and NAD+, whereas …   Wikipedia

  • Fructuronate reductase — In enzymology, a fructuronate reductase (EC number|1.1.1.57) is an enzyme that catalyzes the chemical reaction:D mannonate + NAD+ ightleftharpoons D fructuronate + NADH + H+Thus, the two substrates of this enzyme are D mannonate and NAD+, whereas …   Wikipedia

  • List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia

  • Metabolism — Cell metabolism redirects here. For the journal, see Cell Metabolism. Structure of adenosine triphosphate, a central intermediate in energy metabolism Metabolism (from Greek: μεταβολή metabolē , change or Greek: μεταβολισμός metabolismos,… …   Wikipedia

  • List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia

  • xylulose — threo Pentulose; a 2 ketopentose. l X. appears in the urine in cases of essential pentosuria; it is also an intermediate in the glucuronate pathway. SYN: xyloketose. x. 5 phosphate the d isomer is an intermediate in the pentose phosphate …   Medical dictionary

  • trimetrexate — An antineoplastic agent and antiprotozoal orphan drug used in the treatment of Pneumocystis carinii pneumonia in AIDS patients. * * * tri·me·trex·ate .trī mi trek .sāt n a toxic drug structurally related to methotrexate that is administered in… …   Medical dictionary

  • List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia

  • Hydrolase — Cristal de lysozyme Les hydrolases constituent une classe d enzymes qui catalysent les réactions d hydrolyse de molécules suivant la réaction générale : R R + H2O ⇌ R OH + R H On y trouve par exemple les estérases, qui hydrolysent les …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”