- Cyclohexanol dehydrogenase
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cyclohexanol dehydrogenase Identifiers EC number 1.1.1.245 CAS number 63951-98-4 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a cyclohexanol dehydrogenase (EC 1.1.1.245) is an enzyme that catalyzes the chemical reaction
- cyclohexanol + NAD+
cyclohexanone + NADH + H+
Thus, the two substrates of this enzyme are cyclohexanol and NAD+, whereas its 3 products are cyclohexanone, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cyclohexanol:NAD+ oxidoreductase. This enzyme participates in caprolactam degradation.
References
- Dangel W, Tschech A and Fuchs G (1989). "Enzyme-reactions involved in anaerobic cyclohexanol metabolism by a denitrifying Pseudomonas species". Arch. Microbiol. 152 (3): 273–279. doi:10.1007/BF00409663. PMID 2505723.
- Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1–7. doi:10.1111/j.1432-1033.1975.tb20968.x. PMID 1261.
- Trower MK, Buckland RM, Higgins R, Griffin M (1985). "Isolation and Characterization of a Cyclohexane-Metabolizing Xanthobacter sp". Appl. Environ. Microbiol. 49 (5): 1282–1289. PMC 238543. PMID 16346796. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=238543.
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