Carbonyl reductase (NADPH)
- Carbonyl reductase (NADPH)
In enzymology, a carbonyl reductase (NADPH) (EC number|1.1.1.184) is an enzyme that catalyzes the chemical reaction
:R-CHOH-R' + NADP+ R-CO-R' + NADPH + H+
Thus, the two substrates of this enzyme are R-CHOH-R' and NADP+, whereas its 3 products are R-CO-R', NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is secondary-alcohol:NADP+ oxidoreductase. Other names in common use include aldehyde reductase 1, prostaglandin 9-ketoreductase, xenobiotic ketone reductase, NADPH-dependent carbonyl reductase, ALR3, carbonyl reductase, nonspecific NADPH-dependent carbonyl reductase, aldehyde reductase 1, and carbonyl reductase (NADPH). This enzyme participates in arachidonic acid metabolism.
tructural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1CYD, PDB link|1WMA, PDB link|2HRB, and PDB link|2PFG.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|89700-36-7."
Gene Ontology (GO) codes
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